Extracting method of valerine

A kind of extraction method, the technology of valerian, applied in the field of extraction of natural quaternary ammonium alkaloids

Inactive Publication Date: 2008-10-08
HEFEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no domestic manufacturer producing similar products, and the preparation made from valerian is still blank in China.

Method used

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  • Extracting method of valerine
  • Extracting method of valerine
  • Extracting method of valerine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Add 4Kg of dried valerian root to 5L ether, soak for 5d at room temperature, after suction filtration, add 5L ether to the residue, and continue soaking for 5d. Evaporate the dregs and soak them three times with 5 L of chloroform-methanol mixture (5d, 5d, 4d). Then the solvent was recovered by vacuum evaporation to obtain a viscous oil, which was diluted with 80ml of methanol, then diluted with 120ml of chloroform, added with 1L of ether, and left overnight in the refrigerator; the oily precipitate was extracted with 100ml of 1% hydrochloric acid, and the aqueous solution extracted the oily precipitate Extract three times with 20 ml of 1% hydrochloric acid solution. The mixed aqueous solutions were combined, neutralized with sodium bicarbonate to pH 8-10, extracted 12 times with 75 ml of chloroform-ethanol mixture, and the solvent was evaporated. The 60g residue was eluted by silica gel chromatography, chromatographic silica gel 1kg, the eluent was chloroform-methanol ...

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Abstract

The invention discloses a valerianine distillation method. After being ground, the valerianine is degreased through aether which is a solvent with low boiling point; after that the valerianine is marinated in t chloroform methanol mixture for distillation; the target product valerianine A is produced through dilute hydrochloric acid extraction process, together with silica gel and alumina column chromatographic separation process and recrystalization process. The purity of the valerianine A reaches 98%, satisfying requirements to medical materials. Valerianine is a natural quaternary ammonium alkaloid and has antidepressant function and sedative, hypnotic and anti-convulsion effects.

Description

technical field [0001] The invention relates to a method for extracting natural quaternary ammonium alkaloids, which are N-p-hydroxyphenethyl derivatives of actinidine, and are one of the main effective components of valerian root for antidepressant, sedative, hypnotic and anticonvulsant effects. Background technique [0002] With the development of society, the acceleration of the pace of life, and the intensification of competition, people's mental stress is also gradually increasing. More and more people are paying attention to drugs that can relieve mental tension, regulate qi and calm the nerves, and promote sleep. However, most of the commodities with similar effects sold on the market are synthesized by chemical methods. After taking it, it will cause obvious side effects and discomfort symptoms to the nervous system, and produce drug dependence. Therefore, the market is in urgent need of a drug or health food that is safe and effective, has no side effects, can help...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/04A61P25/20A61K36/185
Inventor 朱仁发何勇
Owner HEFEI UNIV
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