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Blood gas analyzer quality control serum production process

A technology of blood gas analyzer and production method, which is applied in the field of blood gas analyzer quality control products, and can solve the problems that the gas concentration cannot reach the expected value and affect product quality, etc.

Inactive Publication Date: 2008-11-19
上海丰德生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Using the above traditional method, since a certain amount of air will be sealed between the liquid and the bottle mouth, a certain volume of air is sealed in the bottle when the ampoule bottle mouth is heated and sealed. This section is sealed between the liquid level in the ampoule bottle and the bottle After the gas exchange between the air and the liquid reaches equilibrium, the gas concentration (partial pressure) in the liquid will definitely be changed, resulting in the gas concentration not reaching the expected value, thus affecting product quality

Method used

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  • Blood gas analyzer quality control serum production process
  • Blood gas analyzer quality control serum production process
  • Blood gas analyzer quality control serum production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The production process steps are as follows:

[0034] 1) Prepare quality control liquid, its main components and concentrations are as follows:

[0035] name

[0036] 2) Prepare mixed balance gas:

[0037] In order to meet the gas requirements, we use a mixture of pCO2 of 57mmHg, pO2 of 40mmHg and nitrogen as the balance gas as the filling gas for the sealed bottle. The reason why the gas partial pressure range of the balance gas is slightly wider than the required range of the quality control substance is that when the balance gas and the gas in the liquid reach equilibrium, the gas partial pressure in the liquid can reach our pre-designed range.

[0038] 3) Filling:

[0039] Connect the prepared quality control liquid and gas into the corresponding pipeline for filling: the gas is injected into the ampoule first, after the existing air in the bottle is driven out of the bottle mouth, the injection is continued, and then the liquid is injected.

[0040] 4)...

Embodiment 2

[0046] The production process steps are as follows:

[0047] 1) Prepare quality control liquid, its main components and concentrations are as follows:

[0048] name

[0049] 2) Prepare mixed balance gas:

[0050] In order to meet the gas requirements, we use a mixture of pCO2 of 67mmHg, pO2 of 44mmHg and nitrogen as the balance gas as the filling gas for the sealed bottle. The reason why the gas partial pressure range of the balance gas is slightly wider than the required range of the quality control substance is that when the balance gas and the gas in the liquid reach equilibrium, the gas partial pressure in the liquid can reach our pre-designed range.

[0051] 3) Filling:

[0052] Connect the prepared quality control liquid and gas into the corresponding pipeline for filling: the gas is injected into the ampoule first, after the existing air in the bottle is driven out of the bottle mouth, the injection is continued, and then the liquid is injected.

[0053] 4)...

Embodiment 3

[0059] The production process steps are as follows:

[0060] 1) Prepare quality control liquid, its main components and concentrations are as follows:

[0061] name

[0062] 2) Prepare mixed balance gas:

[0063] In order to meet the gas requirements, we use a mixture of pCO2 of 60mmHg, pO2 of 38mmHg and nitrogen as the balance gas as the filling gas for the sealed bottle. The reason why the gas partial pressure range of the balance gas is slightly wider than the required range of the quality control substance is that when the balance gas and the gas in the liquid reach equilibrium, the gas partial pressure in the liquid can reach our pre-designed range.

[0064] 3) Filling:

[0065] Connect the prepared quality control liquid and gas into the corresponding pipeline for filling: the gas is injected into the ampoule first, after the existing air in the bottle is driven out of the bottle mouth, the injection is continued, and then the liquid is injected.

[0066] 4)...

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Abstract

The invention discloses a production method of quality control products of a blood gas analyzer, which comprises the following steps of: preparing a quality control liquid which includes an HEPES buffer solution with concentration of 30 to 50mmol / L; preparing an equilibrium gas which is a mixed gas of CO2, O2 and nitrogen gas; connecting the prepared quality control liquid and equilibrium gas into the corresponding pipelines respectively, meanwhile filling the liquid and gas into an ampoule bottle; and drawing out the pipelines from the ampoule after the volume of quality control liquid filled into the ampoule bottle reach the required level, meanwhile using high temperature flames to seal the bottle. The method is to fill the mixed gas of O2, CO2 and N2 by a predetermined ratio to the ampoule bottle, add the prepared quality control liquid while filling gas, and seal the bottle in the meanwhile. Therefore, the produced quality control substances will not change the predicted gas concentration level due to bottle sealing to a great extent, so the quality of the produced quality control products is reliable.

Description

technical field [0001] The invention relates to a production method of a quality control product of a blood gas analyzer. Background technique [0002] The basic feature of life is to continuously take in nutrients, water, inorganic salts and oxygen from the environment, while constantly discharging waste and exhaling carbon dioxide. The body needs oxygen for oxidative processes in the body and primarily for energy metabolism. In the absence or lack of oxygen, the energy release is incomplete, O 2 In the process of being used by the body, CO is produced 2 and excreted from the body, this consumption of O 2 produce CO 2 In the process of blood circulation, it depends on the gas exchange system of the body, and blood plays an important role in gas exchange. [0003] Generally speaking, blood gas refers to the O contained in the blood 2 and CO 2 gas. Blood gas analysis is a necessary index to evaluate the patient's respiration, oxidation and acid-base balance status. I...

Claims

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Application Information

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IPC IPC(8): G01N33/96
Inventor 姜云飞
Owner 上海丰德生物医药科技有限公司
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