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Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof

A technology for platelets and compositions is applied in the field of pharmaceutical compositions for the treatment of idiopathic thrombocytopenic purpura and the preparation thereof, which can solve the problems of uncertain curative effect, no standardized treatment plan, carcinogenesis and the like, and achieve increased and decreased platelet production and release. Capillary fragility, the effect of promoting differentiation and maturation

Active Publication Date: 2008-12-03
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The efficacy of these drugs is uncertain, with considerable metabolic or carcinogenic adverse consequences
The latest Rituximab (anti-CD20 monoclonal antibody) can achieve a curative effect of 44% to 55.1%, but it is still prone to recurrence and expensive
There are many reports on the treatment of ITP with traditional Chinese medicine, but there are not many definite curative effects. Most of them are clinical observations with small samples. Especially for refractory ITP (RITP), there is no effective prevention and treatment drug, and there is no standardized treatment plan. Large-sample research failed to strictly follow the requirements of Evidence-Based Medicine (EBM), which made the conclusions lack of scientificity and reliability, and was not conducive to popularization and application, and did not meet the development requirements of modern Chinese medicine.

Method used

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  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof
  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof
  • Medicament composition for treating idiopathic thromboeytopenic purpura and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Preparation of granules of the invention:

[0150] Weigh the following raw materials (g): Raw Astragalus 240, Ligustrum lucidum 200, Raw Atractylodes macrocephala 120, Fried White Peony 120, Shouwu 200, Dodder 150, Fried Danpi 120, Fried Citrus aurantium 60, Agrimony 300, Jing Tiansanqi 150, Forsythia 150, Roasted Licorice 60.

[0151] The preparation method is:

[0152] The above-mentioned traditional Chinese medicine is formulated in parts by weight, soaked in water, and decocted twice in water. Fry for 2h after reaching the boiling point for the first time, fry for 1h after reaching the boiling point for the second time, discard the residue, filter and combine the two filtrates, precipitate for 12h, take the supernatant and concentrate it into a thick paste, add 50% white dextrin and appropriate amount of stevia , 60 ℃ low temperature, concentrated into dry paste powder, made into brown fine granules and then divided into 12g / bag.

Embodiment 2

[0154] Preparation of oral liquid of the present invention:

[0155] Weigh the following raw materials (g): Raw Astragalus 240, Ligustrum lucidum 200, Raw Atractylodes macrocephala 120, Fried White Peony 120, Shouwu 200, Dodder 150, Fried Danpi 120, Fried Citrus aurantium 60, Agrimony 300, Jing Tiansanqi 150, Forsythia 150, Roasted Licorice 60.

[0156] The preparation method is:

[0157] The above-mentioned traditional Chinese medicine is formulated in parts by weight, soaked in water, and decocted twice in water. Fry for 1 h after reaching the boiling point for the first time, and fry for another 0.5 h after reaching the boiling point for the second time. Discard the residue and filter and combine the two filtrates. Leave to settle for 12 h. Take the supernatant and concentrate it to an appropriate amount. Stir evenly to make full volume, and dispense into 200ml bottles.

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Abstract

The invention relates to a medicine composition for treating idiopathic thrombocytopenic purpura and a preparation method thereof. The medicine composition comprises the following composition raw material preparations: raw astragalus, ligustrum lucidum, raw rhizoma atractylodis, fried white peony root, radix polygoni multiflori preparata, dodder, fried cortex moutan, fried bitter orange, agrimony, aizoon stonecrop, forsythia and roasted glycyrrhiza; granules or oral liquid can be prepared by the method of the invention; and the medicine composition prepared by the method of the invention has the advantages of safety, effectiveness, stability and economy, is suitable for Chinese basic conditions and can be popularized and applied.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating idiopathic thrombocytopenic purpura and a preparation method thereof, in particular to a pharmaceutical composition for treating idiopathic thrombocytopenic purpura prepared by using traditional Chinese medicine as a raw material and a preparation method thereof. Background technique [0002] Idiopathic thrombocytopenia purpura (Idiopathic thrombocytopenia purpura, ITP) is a syndrome in which the destruction of platelets increases due to immune mechanisms. The clinical manifestations are bleeding from the skin, mucous membranes and internal organs. This disease is a common disease of the blood system, accounting for about 70% of hemorrhagic diseases. It often recurs and is difficult to heal. It can be life-threatening due to complicated intracranial hemorrhage and severe visceral hemorrhage. [0003] Glucocorticoids are the first choice for the treatment of this disease. The short-term effec...

Claims

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Application Information

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IPC IPC(8): A61K36/75A61K9/16A61K9/10A61P7/04
Inventor 周永明黄振翘李峻
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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