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Glycerol fruit sugar injection and preparation method thereof

A technology of injection and glycerin, which is applied in the fields of blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., and can solve problems such as slow onset of action, short duration of drug effect, water and electrolyte disorders, etc.

Active Publication Date: 2008-12-24
AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

3. Water and electrolyte disturbance
It solves the problem of crystals easily appearing in single-use mannitol injection, the problem of intracranial pressure rebound caused by high mannitol concentration, the problem of osmotic nephropathy (or mannitol nephropathy), and the short duration of drug effect; Dehydration and antihypertensive effects of single-use glycerol-fructose injection (composed of glycerin, fructose, sodium chloride, and water for injection) or glycerol-sodium chloride injection (formula of glycerin, sodium chloride, and water for injection) are slow to take effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1 (specification: 250ml)

[0040] The weight of each composition in the prescription of preparing 250000ml glycerin fructose injection is as follows:

[0041] Glycerin 15kg Fructose 6.25kg Mannitol 10kg

[0042] Sorbitol 10kg Glucose 6.25kg Sodium Chloride 2.25kg

[0043] Add water for injection to 250000ml

[0044] The preparation process is as follows:

[0045] Accurately weigh 15kg mannitol and 10kg sorbitol, add 50000ml water for injection, heat the water for injection until the temperature of the water for injection reaches 80°C, and heat while stirring to dissolve all mannitol and sorbitol; accurately weigh 6.25kg fructose, 6.25kg Glucose, 2.25kg sodium chloride are added in the above-mentioned solution, stir to make it dissolve completely, heat to boiling, take by weighing 2500g needle-use active carbon and add in the liquid medicine, stir for 15 minutes and then stand still for 40 minutes, stirring and standing process Keep the liquid temperature ...

Embodiment 2

[0046] Embodiment 2 (specification: 250ml)

[0047]The weight of each composition in the prescription of preparing 250000ml glycerin fructose injection is as follows:

[0048] Glycerin 20kg Fructose 6.25kg Sodium Chloride 2.25kg

[0049] Sorbitol 20kg Glucose 6.25kg

[0050] Add water for injection to 250000ml

[0051] The preparation process is as follows:

[0052] Accurately weigh 20kg of sorbitol, add 50000ml of water for injection, heat the water for injection until the temperature of the water for injection reaches 70°C, heat while stirring to dissolve all the sorbitol; accurately weigh 6.25kg of fructose, 6.25kg of glucose, 2.25kg of sodium chloride Add to the above solution, stir to dissolve completely, heat to boiling, weigh 2000g of activated carbon for needles and add it to the liquid medicine, stir for 10 minutes and then let it stand for 30 minutes. The temperature of the liquid medicine during the stirring and standing process is kept at 85°C After standing fo...

Embodiment 3

[0053] Embodiment 3 (specification: 250ml)

[0054] The weight of each composition in the prescription of preparing 250000ml glycerin fructose injection is as follows:

[0055] Glycerin 30kg Fructose 6kg Mannitol 10kg

[0056] Sorbitol 5kg Glucose 6kg Sodium Chloride 2.25kg

[0057] Add water for injection to 250000ml

[0058] The preparation process is as follows:

[0059] Accurately weigh 10kg mannitol and 5kg sorbitol, add 100000ml water for injection, heat the water for injection until the temperature of the water for injection reaches 70°C, heat while stirring to dissolve all mannitol and sorbitol; accurately weigh 6kg fructose, 6kg glucose, 2. Add 25kg of sodium chloride into the above solution, stir to dissolve it completely, heat to boiling, weigh 1800g of active carbon for needles and add it to the liquid medicine, stir for 15 minutes and then let it stand for 60 minutes. Keep the temperature at 90°C, and remove the activated carbon after standing for 60 minutes; ...

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Abstract

The invention relates to a glycerol levulose injection liquid and a preparation method thereof, belonging to the technical field of medicine preparation. The invention provides the clinic with a composite dehydrating and depressurizing preparation which takes effective quickly in terms of dehydration and depressurization, achieves long effect maintaining, few side effects, can provide energy support and is stable in terms of medicinal liquid. The prescription of the glycerol levulose injection liquid provided by the invention is composed of glycerol, fructose, mannitol, sorbitol, glucose and sodium chloride, injection water. The preparation process is as the following: the mannitol, sorbitol, fructose and glucose are heated and dissolved with the addition of a certain amount of water, undergoes active carbon absorption and decarbonization and is then added with glycerol and a certain amount of injection water; the PH value of the medicinal liquid is adjusted after the treatment of active carbon absorption and is separately placed after a content qualification; the glycerol levulose injection liquid is obtained after sterilization of the medicinal liquid. The key of the preparation method lies in the technical parameters such as whole-process temperature control, material addition sequence, time for heating and standing static, the amount of the active carbon, active carbon absorption time, PH value of the medicinal liquid, etc.

Description

technical field [0001] The present invention relates to glycerol fructose injection and its preparation method, and relates to a pharmaceutical preparation for treating acute and chronic intracranial hypertension caused by cerebrovascular disease, traumatic brain injury, brain tumor, intracranial inflammation and other causes and its preparation method , belongs to the technical field of medicine preparation. Background technique [0002] Acute and chronic intracranial hypertension caused by cerebrovascular disease, traumatic brain injury, brain tumor, intracranial inflammation and other causes are common diseases in clinical practice. Due to the great differences in patients' symptoms, age, gender, physical fitness and disease course, etc., Selecting the appropriate drug to reduce intracranial pressure is a difficult problem often encountered by clinicians. At present, the drugs commonly used in clinic to reduce intracranial pressure include: mannitol injection, glycerin i...

Claims

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Application Information

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IPC IPC(8): A61K31/047A61K31/7004A61K9/08A61P3/12A61P7/10A61P43/00
Inventor 庄洪波
Owner AOLING BODA MEDICINE SCI & TECH DEV BEIJING
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