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Coronary heart disease drop pill and preparation method thereof

A technology of coronary heart salvia miltiorrhiza and dripping pills, which is applied in the field of traditional Chinese medicine, and can solve the problems of large differences in active ingredient content, differences in bioavailability and curative effect, etc.

Active Publication Date: 2009-01-07
哈尔滨业锐药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because Danshen and Panax notoginseng contain a variety of active ingredients, among them, the active ingredients in Danshen are divided into two parts: fat-soluble components and water-soluble components. Different extraction conditions, the content of active ingredients in the obtained extracts is different. large, which directly leads to significant differences in the bioavailability and efficacy of the final product

Method used

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  • Coronary heart disease drop pill and preparation method thereof
  • Coronary heart disease drop pill and preparation method thereof
  • Coronary heart disease drop pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of embodiment 1 dropping pill

[0032] Take each crude drug by the following weight: Salvia miltiorrhiza 1600g, Panax notoginseng 1600g, balsamic oil 14g (or 14ml);

[0033] Grind the salvia miltiorrhiza into fine particles, extract twice with 95% alcohol, the amount of alcohol added is 4 times the amount of the medicinal material, extract for 2 hours for the first time, extract for 1.5 hours for the second time, filter, combine the filtrates, and recover ethanol under reduced pressure , get liquid medicine 1, set aside;

[0034]Evaporate the dregs of Danshen to dry ethanol, then extract 3 times with 70% ethanol, the amount of alcohol added is 4 times the amount of medicinal materials, the first extraction is 1 hour, the second and third extractions are 0.5 hours, filtered, combined filtrates, concentrated To about 5300ml (0.3g crude drug / ml), adjust the pH to 3.0 with 10% hydrochloric acid, let stand, centrifuge to remove precipitation, get the superna...

Embodiment 2

[0038] Take each crude drug by the following weight: Salvia miltiorrhiza 1600g, Panax notoginseng 1600g, balsamic oil 14g (or 14ml); Salvia miltiorrhiza is crushed into fine particles, extracted 2 times with 95% alcohol, and the amount of alcohol added is 5 times the amount of medicinal materials, Extract for 70 minutes each time, filter, combine the filtrates, and recover ethanol under reduced pressure to obtain medicinal solution 1, which is set aside;

[0039] Drain the dregs of Salvia miltiorrhiza to dry ethanol, decoct 3 times with 8 times the amount of water, 1 hour each time, filter, combine the filtrate, concentrate, pass through the pretreated macroporous adsorption resin column D101, wash with water until the eluent is free color, then eluted with 80% ethanol until nearly colorless, collected the 80% ethanol eluate, concentrated to obtain medicinal solution 2, and set aside;

[0040] Grind Panax notoginseng into fine particles, heat and reflux extract with 4 times th...

Embodiment 3

[0043] Take by weighing each crude drug by following weight: Salvia miltiorrhiza 1600g, Panax notoginseng 1600g, balsamic oil 14g (or 14ml); Salvia miltiorrhiza is pulverized into fine particles, extracts 2 times with 95% alcohol, and the amount of alcohol added is 4 times the amount of medicinal materials, Extract for 2 hours for the first time, 1.5 hours for the second extraction, filter, combine the filtrates, recover ethanol under reduced pressure, and obtain medicinal solution 1, and set aside;

[0044] Drain the dregs of Salvia miltiorrhiza to dry ethanol, then extract 3 times with 4 times the amount of 50% ethanol, extract for 1 hour for the first time, extract for 0.5 hours for the second and third times, filter, combine the filtrates, and concentrate to about 5300ml (0.3g crude drug / ml), adjust the pH to 3.0 with 10% hydrochloric acid, let it stand, centrifuge to remove the precipitate, get the supernatant, and pass through the D101 resin column (the ratio of medicina...

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Abstract

The invention discloses a method for preparing Guangxindanshen Dripping Pill, which comprises the steps of: (1) extracting Salvia miltiorrhiza with 75-95% ethanol, filtering to obtain a filtrate, and recovering ethanol from the filtrate under reduced pressure; (2) extracting Salvia miltiorrhiza residue with water or 30-70% ethanol, filtering to obtain a filtrate, concentrating the filtrate, standing, centrifuging, collecting supernatant, and adsorbing with a resin column; (3) rinsing with water, eluting with 30-70% ethanol, collecting eluate, and recovering ethanol under reduced pressure; (4) extracting Panax notoginseng with 30-70% ethanol to obtain an extractive solution, filtering the extractive solution, concentrating, standing, filtering to obtain a filtrate, and adsorbing with a resin column; and rinsing with water, eluting with 30-70% ethanol, collecting eluate, and recovering ethanol under reduced pressure; (5) mixing the above medicinal solutions, and concentrating to obtain a concentrated extract; and (6) mixing the concentrated extract with a matrix material, stirring, adding rosewood oil, mixing, sealing, keeping temperature, and making into dripping pill. The inventive dripping pill has remarkable improvements in terms of contents of effective ingredients, bioavailability, etc.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Guanxin Danshen dripping pills for treating coronary heart disease angina pectoris, belonging to the field of traditional Chinese medicines. Background technique [0002] Guanxin Danshen Tablet is a traditional Chinese medicine preparation with definite curative effect for treating coronary heart disease angina pectoris. Become medium powder, according to the percolation method (Appendix I) under the liquid extract and extract item, use 90% ethanol as solvent to carry out percolation, collect the percolation liquid, reclaim ethanol and concentrate into thick paste; Once, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to an appropriate amount, add the above-mentioned fine powder and thick paste, stir well, make granules, dry, spray with balsamic oil, mix well, press into 1000 tablets, pack ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/20A61K47/34A61P9/10A61K47/10
Inventor 戴浩
Owner 哈尔滨业锐药业有限公司
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