Medicament composition for treating roundworm disease and preparation method thereof

A composition and medicine technology, applied in the field of pharmaceutical compositions for treating ascariasis and preparation thereof, can solve the problems of unsatisfactory, high cost, high toxicity and the like, and achieve the effects of safe use, reduced toxicity and low cost

Inactive Publication Date: 2009-01-14
广东宏兴集团股份有限公司宏兴制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for the treatment of ascariasis at home and abroad. Western medicines mainly include albendazole, mebendazole, piperazine citrate, pyrantel, levamisole, etc. Traditional Chinese medicines include Wumei Wan, Kudongpi, partridge, etc. , but most of them are not ideal. Some have a large amount of clinical application, low egg conversion rate, and high cost. Although some have a high rate of worm removal, they are highly toxic and have some adverse reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: the preparation of powder

[0057] Take 500 parts by weight of partridge, heat and reflux three times with 70% ethanol, each time for 1.5 hours, combine the three extracts to recover ethanol to an appropriate amount, filter, concentrate the filtrate to a relative density of 1.00-2.00 (20°C), add 20% lime Appropriate amount of milk, stir for 4 hours, add an equal volume of 95% ethanol to stir, let stand for 1 hour, filter, wash the residue twice with 50% ethanol, combine the filtrate and lotion, recover ethanol under reduced pressure, make a thick paste, and dry under reduced pressure , crushed into fine powder; take 5 parts by weight of levamisole hydrochloride and grind into fine powder, add appropriate amount of starch, mix well, and fully mix with the above fine powder to obtain final product.

Embodiment 2

[0058] Embodiment 2: the preparation of capsule

[0059] Take 3000 parts by weight of partridge, heat and reflux three times with 70% ethanol, each time for 1.5 hours, combine the three extracts to recover ethanol to an appropriate amount, filter, concentrate the filtrate to a relative density of 1.00-2.00 (20°C), add 20% lime Appropriate amount of milk, stir for 4 hours, add an equal volume of 95% ethanol to stir, let stand for 1 hour, filter, wash the residue twice with 50% ethanol, combine the filtrate and lotion, recover ethanol under reduced pressure, make a thick paste, and dry under reduced pressure , crushed into fine powder; take 30 parts by weight of levamisole hydrochloride and grind into fine powder, add appropriate amount of starch, mix well, fully mix with the above fine powder, fill, and make capsules.

Embodiment 3

[0060] Embodiment 3: the preparation of tablet

[0061] Take 1000 parts by weight of partridge, heat and reflux three times with 70% ethanol, each time for 1.5 hours, combine the three extracts to recover ethanol to an appropriate amount, filter, concentrate the filtrate to a relative density of 1.00-2.00 (20°C), add 20% lime Appropriate amount of milk, stir for 4 hours, add an equal volume of 95% ethanol to stir, let stand for 1 hour, filter, wash the residue twice with 50% ethanol, combine the filtrate and lotion, recover ethanol under reduced pressure, make a thick paste, and dry under reduced pressure , crushed into fine powder; take 15 parts by weight of levamisole hydrochloride and grind into fine powder, add appropriate amount of starch, mix well, fully mix with the above fine powder, granulate, dry, add magnesium stearate, and press into tablet.

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PUM

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Abstract

The present invention provides a medicinal compound for curing ascariasis and a preparation method thereof. The medicinal compound contains the components with the following weight portions: 500 to 3,000 portions of fucus helminthochrtus and 5 to 30 portions of levamisole hydrochloride. The present invention adopts the integrated traditional Chinese and western medicine, selects the folk customary medicine--- fucus helminthochrtus and is fitted with a small amount of wide-spectrum anthelmintic--- levamisole hydrochloride; the appropriate proportion is selected through a number of experiments. The two components are reduced and mixed according to the proportion of the present invention, thus maintaining the anthelmintic function; fucus helminthochrtus is utilized to inhibit the breath of ascarid cells so as to hinder the energy and further cause spastic paralysis and even death of ascarid; and due to the reduced amount of the two components, the dosage of levamisole hydrochloride is relatively reduced, thus decreasing the toxicity and ensuring safe use, good curing effect and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating ascariasis and a preparation method thereof. Background technique [0002] Ascariasis is a parasitic disease in which roundworms live in the human small intestine. Both adults and children can be infected, but it is more common in children aged 5 to 15. The incidence rate is higher in rural areas than in cities, and higher in temperate zones than in frigid zones. Mild cases are asymptomatic, slightly severe cases have mental, gastrointestinal symptoms, and malnutrition, and severe cases can cause biliary ascariasis or roundworm intestinal obstruction. At present, there are many drugs for the treatment of ascariasis at home and abroad. Western medicines mainly include albendazole, mebendazole, piperazine citrate, pyrantel, levamisole, etc. Traditional Chinese medicines include Wumei Wan, Kudongpi, partridge, etc. , but many are not ideal....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/02A61K9/16A61K9/20A61K9/48A61P33/14A61K31/429
Inventor 李志勇张惜强赖怀恩苏和明郑少鑫
Owner 广东宏兴集团股份有限公司宏兴制药厂
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