Stable state vitamin K3and method of preparing the same

A vitamin and stable state technology, applied in the field of stable vitamin K3 and its preparation, can solve the problem of high cost, achieve high economic efficiency, high biological activity, and inhibit the formation of isomers

Inactive Publication Date: 2009-01-21
SHANDONG DAHUA GUANGJI BIOCHEM ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has only about 50% yield for the valuable intermediate menadione, and consumes 20% more nicotinamide, so the cost is higher; (2) wi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]In the weight ratio: n (menadione): n (sodium metabisulfite): n (nicotinamide): n (sulfuric acid) = 1: 1.5: 0.8: 0.4 under certain conditions to synthesize stable vitamin K3 (MNB), on The yield of menadione can be increased to more than 75%, which greatly reduces the production cost and has extremely high economic and social benefits. The specific operation is as follows: add 100g (100%) menadione and 300ml of 80% alcohol aqueous solution into a 500ml reaction bottle, stir well for beating, then add 150g of sodium metabisulfite (content > 98%) and react at 40-50°C for 2 hours to reach a solution To clarify, add 85g of nicotinamide (content > 99%) and continue stirring to dissolve, then slowly add sulfuric acid dropwise to adjust the pH to 3-5 to obtain a large amount of white crystals, filter, wash, and dry to obtain 284.6g of pure high-stable K3, The yield was 75.6% (p-menadione).

Embodiment 2

[0026] The steady state vitamin K 3 , is made of the following materials by weight: 100g of menadione, 150g of sodium metabisulfite, 90g of nicotinamide, and 55g of sulfuric acid.

[0027] The steady state vitamin K 3 The preparation method is as follows: Add 100g of menadione and 300ml of 80% alcohol aqueous solution into a 500ml reaction bottle, stir well for beating, then add 150g of sodium metabisulfite and react at 40-50°C for 2 hours until the solution is clear, add 90g of nicotinamide and continue stirring to dissolve , and then slowly drop 55 grams of sulfuric acid to adjust the pH=3 to 5 to obtain a large amount of white crystals, which were filtered, washed and dried to obtain 285.8 g of pure high-stable K3 with a yield of 76.0%.

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PUM

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Abstract

The invention discloses a vitamin K, in particular a steady-state vitamin K3 and a preparation method thereof. The steady-state vitamin K3 is characterized by being made from the following materials: menadione, sodium metabisulfite, niacinamide and sulphuric acid. The preparation method of the steady-state vitamin K3 comprises the steps as follows: the menadione and alcohol water blend are added to a 500ml reaction bottle, fully stirred and pulped, and then the sodium metabisulfite and the niacinamide are added and continuously stirred to facilitate dissolution, the sulphuric acid is slowly added dropwise, and the pH is regulated to 3-5 to obtain a great amount of white crystals, and the white crystals are filtered, washed and dried to obtain the pure K3 with high steady state. The vitamin K3 has high biological activity and maintains vitamin PP efficiency which is the inherent nutritional function of the niacinamide group in MNB structure, that is, a product has the two functions of vitamin K3 and vitamin PP simultaneously, so the vitamin K3 has higher economical efficiency.

Description

(1) Technical field [0001] The present invention relates to a vitamin K, in particular to a stable vitamin K 3 and its preparation method. (2) Background technology [0002] Vitamin K is a derivative of menadione, also known as blood coagulation vitamin or anti-bleeding vitamin, it is a vitamin necessary for the formation of prothrombin in animals. There are two types of vitamin K found in nature: phylloquinone found in green plants, known as vitamin K 1 , another menaquinone synthesized by animals' intestines and other microorganisms, known as vitamin K 2 . Synthetic vitamin K 3 、K 4 . Vitamin K 1 It can also be synthesized artificially. Vitamin K 3 It has high activity, is water-soluble, and is easy to use, so it is the most widely used. The main physiological function of vitamin K is to promote the synthesis of thrombin and coagulation factors VII, IXX in the liver, and activate it to participate in the blood coagulation process. Vitamin K deficiency in animals...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K31/455A61P3/02A23K1/16A23K20/174A23K40/00
Inventor 陈林世史兰东邢良勇刘云霞
Owner SHANDONG DAHUA GUANGJI BIOCHEM ENG
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