Novel pravastatin lactone crystal form
A technology of pravastatin lactone and polymorphism, which is applied to medical preparations containing active ingredients, metabolic diseases, cardiovascular system diseases, etc., and can solve the problem of pravastatin lactone purification, crystal form and preparation method. And other issues
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Embodiment 1
[0037] Embodiment 1: Preparation of type A polycrystal
[0038] Dissolve 4.0 g of pravastatin in 20 mL of acetone, and stir at 30° C. for 0.5 h. 10 mL of petroleum ether was added to the mixture and stirred at 48 °C for 1 h. The mixture was cooled to room temperature, left standing for 3 h, and the suspension was filtered to obtain pravastatin lactone crystals, which were put into an oven and kept at 50° C. for 12 h to obtain pravastatin lactone type A. The crystal form is characterized by the X-ray powder diffraction pattern shown in Figure 1 .
Embodiment 2
[0039] Embodiment 2: the preparation of type A polycrystal
[0040] Dissolve 10.0 g of pravastatin in 50 mL of acetone, and stir at 30° C. for 0.5 h. 20 mL of petroleum ether was added to the solution, and stirring was continued at 45 °C for 1 h. The mixture was cooled to room temperature, left for 3 hours, filtered, and the obtained crystals were placed in an oven at 50° C. for 12 hours to obtain pravastatin lactone type A. Form A is characterized by the X-ray powder diffraction pattern shown in Figure 1 of the accompanying drawings.
Embodiment 3
[0041] Embodiment 3: the preparation of B type polycrystal
[0042] Dissolve 5.0 g of pravastatin lactone in 10 mL of a mixed solvent of ethanol and water at a volume ratio of 1:1, heat the suspension to 50° C., and stir until the pravastatin lactone is completely dissolved. Add 60 mL of acetonitrile to this mixture, raise the temperature to 77°C, and stir for 1 h. The obtained suspension was filtered, the filter cake was washed once with acetonitrile, and dried naturally to obtain pravastatin lactone type B. Form B is characterized by the X-ray powder diffraction pattern shown in Figure 2 of the accompanying drawings.
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