Traditional Chinese medicine formulation for treating diabetes complication disease
A technology of traditional Chinese medicine preparation, diabetes, applied in the field of traditional Chinese medicine and its preparation
Inactive Publication Date: 2011-03-23
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology
Diabetic complications mainly accumulate in heart, brain, kidney and other organs. At present, there is no drug that can take care of multiple organs. The multi-target and multi-effect characteristics of traditional Chinese medicine compound provide a good opportunity for the development of drugs for the prevention and treatment of diabetes, especially complications. strategy
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[0023] 1. Animal experiments:
[0024] ①. Materials and methods
[0025] Materials: Healthy male SD rats, provided by the Experimental Animal Center of the Fourth Military Medical University, weighing 180g±20g; the inventor is the inventor of the experimental design, implementation and data collation, and the blind evaluation is adopted.
[0026]②. Establishment and grouping of animal models: After the animals were fed for 1 week, a 4.5 g / L solution was prepared with 0.1 mol / L sodium citrate buffer (pH 4.5) and streptozotocin (Sigma product), A single intraperitoneal injection of 50 mg / kg was used, and 30 rats whose fasting blood glucose level reached 16.7 mmol / L were included in the experiment after 72 hours. The rats were divided into two groups by random lottery: Chinese medicine treatment group and diabetes group, 15 rats in each group; at the same time, 15 healthy rats matched with the weight and age of diabetic rats (source as above) were taken as normal controls Group...
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The invention discloses a traditional Chinese herbal preparation for curing diabetes complications, which is prepared by the following main raw drugs with weight prescription ratios: 5 portions to 10 portions of angelica, 5 portions to 10 portions of rhizoma ligustici wallichii, 5 portions to 10 portions of astragalus hoangtchy, 5 portions to 10 portions of radices puerarire, 10 portions to 15 portions of earthworm, 10 portions to 15 portions of Ramuli mori; and though the following technique: angelica, rhizoma ligustici wallichii, astragalus hoangtchy, earthworm, radices puerarire and Ramulimori are selected according to the weight ratio and added with water with the weight of 10 to 15 times, soaked for 24 to 36 hours, and decocted and boiled for 3 times, and then the decoction liquids of the three times are integrated and filtered; the filtrate is collected and concentrated into a dense ointment with a relative density of 1:1.25 to 1.35 for a standby purpose; the dense ointment is roasted at low temperature for 10 hours for obtaining dry ointment powders, and auxiliary materials are added in the weight ratio that the ointment powder : dextrin equals to 1:0.5; and the dry ointment powders are input to capsules separately after being made into grains. The prescription has effects of supplementing qi and nourishing yin, promoting blood circulation and freeing channels, has unique healing effects for making better blood sugar, blood fat and blood circulation obstacles of Type 2 diabetes patients and experimental diabetes rats, promoting the regeneration of micro-blood vessels, protecting the endothelium and the like.
Description
Technical field [0001] The invention belongs to the field of traditional Chinese medicine and its preparation, in particular to a traditional Chinese medicine preparation for treating diabetes, which consists of angelica, chuanxiong, astragalus, kudzu root, earthworm and mulberry. Clinical use and pharmacological experiments have confirmed that the curative effect is good. Background technique [0002] In recent years, due to many factors such as the improvement of living standards, changes in dietary structure, increasingly tense pace of life, and less active and more sedentary lifestyle, the incidence of diabetes worldwide has increased rapidly. Diabetes has become the third largest disease after tumors and cardiovascular diseases. Chronic diseases that seriously threaten human health. According to the World Health Organization, by 2025, the number of adult diabetic patients in the world will increase to 300 million, while the number of diabetic patients in China will re...
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IPC IPC(8): A61K36/605A61K9/48A61P3/10A61K35/64A61K35/62
Inventor 孟华郭军王晓明吴利平高建苑
Owner FOURTH MILITARY MEDICAL UNIVERSITY