Production method of high-assay calcium ascorbate granules capable of directly being compressed

Abstract

The invention discloses a direct-compression production method of high content calcium ascorbate particles. The production method includes: the calcium ascorbate crystalloid raw material is crushed; powder adhesive is added and is mixed evenly with the calcium ascorbate crystalloid raw material; then the mixture is placed in a dry granulator for granules preparation; the granules are placed in a fluidized bed hopper while paste adhesive is sprayed; the granules coated with paste adhesive is dried by the continuously fed wind; direct-compression high content calcium ascorbate particles are obtained after discharging. When the method is adopted, the tablet hardness of prepared particles can reach more than 15 kg; the friability is less than 1%; the compression performance is improved; meanwhile, because the dosage of adhesive is reduced in the production method, the drying time is reduced, so as to avoid the yellow-changing phenomenon of the material; the stability is good.

Description

technical field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a method for producing high-content calcium ascorbate granules capable of direct compression into tablets. Background technique

[0002] In the field of pharmaceutical preparations, many active ingredients are made into tablets, but due to the poor compressibility, fluidity and dispersibility of many active ingredients, they cannot be directly used for tablet compression. In order to overcome this incompatibility To give enough plasticity, it is more common practice to preform the active substance into granules suitable for tableting. In general, granulation is a technique that increases the particle size of a powder in order to convert the powder solids into aggregates of different sizes and porosity, which are known as granules. After being made into granules, it has practical properties, such as dust reduction, better fluidity, good dispersibility, stronge...