Double-cyclitol medicine composition containing surfactant and preparation method thereof

A technology of surfactants and co-surfactants, which is applied in the field of bicyclol-containing surfactant-containing pharmaceutical compositions and its preparation and preparation, can solve the problems of no solid precipitation of bicyclol, and achieve improved bioavailability, Ease of industrialization and reduction of individual differences
CN101390851BActive Publication Date: 2011-03-30BEIJING UNION PHARMA FACTORY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING UNION PHARMA FACTORY
Publication Date
2011-03-30

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Abstract

The invention discloses a bicyclo-ethanol medicine combination which contains surfactant, and the preparation thereof. Bicyclo-ethanol is dissolved in medicine loading substrate which is composed of one or more types of the following ingredients, surfactant, cosurfactant and oil, so as to form the medicine combination which is oily solution or semisolid. The medicine combination in different formulations can be added with water to form emulsion, microemulsion or transparent rapidly. When the medicine combination is taken orally, the absorption of difficult soluble bicyclo-ethanol is enhanced through self-emulsification, self micro-emulsification or solubilization, so as to reduce the individual difference and improve the bioavailability and clinical treatment effect of bicyclo-ethanol. The medicine combination has simple preparation process and is applicable to preparing various preparations. The invention also includes capsules, soft capsules, controlled-release capsule, osmotic pumpcapsules or other proper types of preparation which are prepared through the medicine combination.
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Description

technical field

[0001] The present invention relates to the technical field of solubilization, self-emulsification, self-microemulsification and bioavailability improvement of poorly water-soluble drugs. In the drug-loading matrix composed of one or several components, the drug delivery system is prepared, which can be self-emulsified, self-microemulsified or solubilized in the gastrointestinal tract after oral administration, thereby enhancing the absorption of the insoluble drug bicyclol, reducing individual differences, and improving bicyclol. Alcohol bioavailability and clinical efficacy. Background technique

[0002] Bicyclol is an innovative anti-hepatitis drug with independent intellectual property rights developed by the Institute of Materia Medica, Chinese Academy of Medical Sciences. The bicyclol raw material and its tablets obtained the new drug certificate and production approval in 2001, and are exclusively produced by Peking Union Medical College Pharmaceutica...

Claims

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