Compound with anti-parkinson pharmacological activity

A pharmacological activity, Parkinson's disease technology, applied in the fields of organic chemistry, drug combination, sugar derivatives, etc., can solve the problem that no one has observed the anti-Parkinson's disease pharmacological activity of baicalin.

Inactive Publication Date: 2009-05-20
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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Problems solved by technology

No one has observed the pharmacological acti

Method used

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  • Compound with anti-parkinson pharmacological activity
  • Compound with anti-parkinson pharmacological activity
  • Compound with anti-parkinson pharmacological activity

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Embodiment 1

[0069] The baicalin series yellow powder purchased from the market was formulated into a 0.5% aqueous solution. Since it could not be completely dissolved, the prepared reagent was poured into a beaker and treated with ultrasonic waves for 5min-10min to make a fine particle suspension. The test drug of baicalin was orally administered to animals.

[0070] Compared with the prior art, the technology of the present invention has the following advantages and effects

[0071] 1. The method of extracting baicalin from the traditional Chinese medicine Scutellaria baicalensis is relatively mature, and now baicalin has been used as a substitute for scutellaria baicalensis in various traditional Chinese medicine preparations such as Yinhuang injection, Yinzhihuang injection, Sanhuang tablet, and Huanglian Shangqing tablet. Among them, these preparations are widely used clinically and have no toxic side effects. Pharmacological studies have also proved that the toxicity of baicalin is v...

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Abstract

The invention relates to a compound with anti-parkinsonism pharmacological activity, which is called baicalin, with a systematic name that: the anti-PD pharmacological activity of baicalin acting on two kinds of animals with parkinsonism disease shows that the baicalin can protect the nigrostriatal dopaminergic neurons of animals of a PD model. The research results comprise that: (1) researches are carried out to check whether the baicalin can protect mice with parkinsonism disease induced by 1-methyl-4-phenyl1, 2, 3, 6-tetrahydropyridine (MPTP); and (2) researches are carried out to check whether the baicalin can protect rats with parkinsonism disease induced by rotenone; and the results of the researches shows that the baicalin can protect the nigrostriatal dopaminergic neurons of animals of the PD model, can reduce the loss of the nigrostriatal dopaminergic neurons, promote the growth of dopaminergic neuron protuberances, prevent the reduction of striatum dopamine, decrease the percentage of praxeological change occurring on animals, reduce total praxeological credits and improve the praxeological symptom of PD rats. The pharmacological activity of the baicalin suggests that the baicalin has great application significance in stopping the development of Parkinsonism disease.

Description

technical field [0001] The invention relates to a compound with anti-Parkinson's disease pharmacological activity, belonging to the technical field of medical application. Background technique [0002] Parkinson's disease (PD) is a common degenerative disease of the nervous system. The main clinical symptoms are decreased movement, muscle rigidity, limb tremor, and postural instability. Its incidence rate reaches 1-2% in the population over 60 years old, and there is a gradual upward trend. The etiology of the disease is not yet clear, and it tends to be considered as the result of the joint action of environmental factors and genetic factors. The main pathological changes are the progressive loss of dopaminergic neurons in the substantia nigra and the appearance of Lewy’s bodies in the cytoplasm. Eventually it leads to the lack of dopamine in the striatum, and the imbalance between the dopaminergic nerve function and the cholinergic nerve function in the nigro-striatal sys...

Claims

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Application Information

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IPC IPC(8): C07H17/07A61P25/16
Inventor 陈忻赵晖张楠邹海艳穆阳
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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