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Method for extracting triptolide from Tripterygium wilfordii

A technology of triptolide and triptolide, applied in the field of natural product chemistry, can solve the problems of high cost, small amount of extracted raw materials, difficult operation and the like

Inactive Publication Date: 2009-05-20
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is due to the use of supercritical CO 2 Extraction, high cost, difficult operation, small amount of extracted raw materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 200g of pulverized Tripterygium wilfordii medicinal material (on dry basis), put it in a pressure-resistant extraction kettle, add 1,2-dichloroethane at a material-to-liquid ratio of 1:9, seal the extraction kettle, start stirring, and the stirring speed is 120r / min , the heating rate is 100°C / h, the extraction is at 120°C, the timing starts from reaching the set temperature, and the extraction is 70min. ℃ and concentrated to dryness under reduced pressure, the yield of triptolide was 0.172‰, and the purity was 1.21%.

Embodiment 2

[0017] Take 200g of crushed Tripterygium wilfordii medicinal material (dry basis), put it in a pressure-resistant extraction kettle, add dichloromethane at a material-to-liquid ratio of 1:8, seal the extraction kettle, start stirring, the stirring speed is 120r / min, and the heating rate is 100°C / h, extract at 130°C, start timing from reaching the set temperature, extract for 60min, after the extraction is completed, pass condensed water into the cooling pipe to quickly cool down to 30°C, and after the solid-liquid separation of the extract, concentrate the filtrate under reduced pressure at 60°C to Dry, the yield of triptolide is 0.106‰, and the purity is 1.18%.

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PUM

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Abstract

The invention discloses a method for extracting triptolide from tripterygium wilfordii, which is characterized in that dried tripterygium wilfordii rootstocks are compressed by chloric alkane for extraction. The method comprises the steps that: the dried tripterygium wilfordii rootstocks and the alkane are mixed according to a certain material-liquid ratio and put into a compressing reaction kettle for extraction; solid maters and fluid matters in the mixture obtained by the extraction are separated to obtain an extract solution; after being put together, the extract solution is decompressed and concentrated to obtain triptolide crude products. The operating technology is mainly characterized by simple operation, smooth processes, recyclable reagents, small energy consumption, low production cost, high yield and high purity.

Description

Technical field: [0001] The invention relates to the field of natural product chemistry, in particular to a method for extracting triptolide from triptolide. [0002] The main features of the operation process are simple operation, smooth process, recyclable reagents, less energy consumption, low production cost, high yield and purity. Background technique: [0003] Triptolide is the main active ingredient of Tripterygium wilfordii. It has various pharmacological effects such as anti-inflammation, immunosuppression, anti-fertility, anti-tumor and leukemia treatment. It is clinically used for the treatment of organ transplant rejection, autoimmune diseases, It has remarkable curative effect on nephrotic syndrome and other aspects, and can also be used for the treatment of difficult diseases such as rheumatoid arthritis, rheumatoid arthritis, bruises, glomerulonephritis, lupus erythematosus, and nephrotic syndrome. However, the content of triptolide in Triptolide is very low,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J73/00A61K36/37
Inventor 祖元刚杨磊张琳赵春建李彤祖柏实王化杨逢建路祺孙志强
Owner NORTHEAST FORESTRY UNIVERSITY
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