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Cefaclor orally disintegrating tablet and preparation method thereof

A technology of orally disintegrating tablets and cefaclor, which is applied in the field of medicine, can solve the problems of reducing patient treatment compliance, and achieve the effects of increasing bioavailability, increasing stability, and improving bioavailability and stability

Active Publication Date: 2009-06-03
金鸿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral preparations of cefaclor need to be swallowed with water when taken, which brings a lot of inconvenience to patients with inconvenient water intake or patients with difficulty in swallowing, and reduces the patient's compliance with treatment

Method used

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  • Cefaclor orally disintegrating tablet and preparation method thereof
  • Cefaclor orally disintegrating tablet and preparation method thereof
  • Cefaclor orally disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The content of each component per thousand tablets is as follows:

[0058] Cefaclor…………………………………………………………… 250g

[0059] Polyacrylic resin IV……………………………………………… 30g

[0060] NE30D…………………………………………………… 3g

[0061] Ethyl cellulose…………………………………………………………………………………………30g

[0062] Mannitol………………………………………………………………… 120g

[0063] Cross-linked polyvinylpyrrolidone………………………………………………… 20g

[0064] Low-substituted hydroxypropyl cellulose…………………………………………… 10g

[0065] Micropowder silica gel…………………………………………………………………………3g

[0066] Aspartame………………………………………………………… 10g

[0067] Magnesium stearate………………………………………………………………………………………………5g 5g

[0068] Preparation:

[0069] ①. The polyacrylic resin IV, Dissolve NE30D and ethyl cellulose in an appropriate amount of ethanol and stir thoroughly to dissolve, then add 20% of the prescription amount of micropowder silica gel, keep stirring to suspend the micropowder silica gel evenly, and use it as a capsule material for later use;

[0070]...

Embodiment 2

[0076] The content of each component per thousand tablets is as follows:

[0077] Cefaclor………………………………………………………………… 125g

[0078] Polyacrylic resin IV…………………………………………… 5g

[0079] NE30D………………………………………………… 1g

[0080] Ethyl cellulose………………………………………………………………………5g

[0081] Mannitol……………………………………………………………40g

[0082] Cross-linked polyvinylpyrrolidone……………………………………… 5g

[0083] Low-substituted hydroxypropyl cellulose…………………………………………… 2g

[0084] Micropowder silica gel………………………………………………………………………………………………………………………………………1g

[0085] Aspartame ……………………………………………………… 2g

[0086] Magnesium stearate…………………………………………………………………………… 2g

[0087] Preparation:

[0088] ①. The polyacrylic resin IV, Dissolve NE30D and ethyl cellulose in an appropriate amount of ethanol and stir thoroughly to dissolve, then add 20% of the prescription amount of micropowder silica gel, keep stirring to suspend the micropowder silica gel evenly, and use it as a capsule material for later use;

[0089] ②. Mi...

Embodiment 3

[0095] The content of each component per thousand tablets is as follows:

[0096] Cefaclor………………………………………………………… 62.5g

[0097] Polyacrylic resin IV…………………………………………… 5g

[0098] NE30D…………………………………………………… 0.5g

[0099] Ethyl cellulose………………………………………………………………………5g

[0100] Mannitol……………………………………………………………… 25g

[0101] Cross-linked polyvinylpyrrolidone……………………………………… 4g

[0102] Low-substituted hydroxypropyl cellulose…………………………………………… 2g

[0103] Micropowder silica gel…………………………………………………………………………………………………………………………………………………………………………………………………………………0.6g

[0104] Aspartame ……………………………………………………… 2g

[0105] Magnesium stearate ……………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………………1g

[0106] Preparation:

[0107] ①. The polyacrylic resin IV, Dissolve NE30D and ethyl cellulose in an appropriate amount of ethanol and stir thoroughly to dissolve, then add 20% of the prescription amount of micropowder silica gel, keep stirring to suspend...

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Abstract

The invention discloses a Cefaclor orally disintegrating tablet and a preparation method thereof. The tablet comprises Cefaclor with pharmaceutically effective dose, pharmaceutically acceptable coating material, diluent, disintegrant, glidant, flavouring and lubricant. Ingredients, such as the coating material, the diluent, the disintegrant and the like, and contents are screened, and the preparation technology is improved by numerous studies by the applicant of the invention, thereby obtaining a prepared product with faster effect and more sufficient absorption. The tablet can be disintegrated or dissolved in more than ten seconds in an oral cavity by swallowing without drinking water. The tablet is more suitable for the elderly and patients with solid-swallowing difficulty, and provides great convenience for patients which are busy in work or can not take water conveniently.

Description

technical field [0001] The invention relates to a cefaclor orally disintegrating tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Cefaclor (cefaclor, CCL, cephalexin, trade names: Hikerao, Xindaro, Xin Ke Nuo, Shi Dagong, Kefule, Dafukang), the molecular formula is C 15 h 14 ClN 3 o 4 S·H 2 O, the structural formula is as follows: [0003] [0004] Cefaclor is a second generation oral cephalosporin antibiotic. It was developed by the United States in 1976, approved by the FDA in 1979, and launched in the United States in 1982. In 1985, it replaced cephalexin and became the world's first best-selling antibiotic. In February 1994, Cefaclor was introduced to the Chinese market under the trade name "Xindaro". Because of its outstanding advantages such as broad antibacterial spectrum, high efficiency, good oral absorption, wide tissue distribution, and mild adverse reactions, cefaclor has become an idea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/545A61K9/20A61K47/38A61P31/04
Inventor 上官清
Owner 金鸿药业股份有限公司
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