Cefaclor orally disintegrating tablet and preparation method thereof

Abstract

The invention discloses a Cefaclor orally disintegrating tablet and a preparation method thereof. The tablet comprises Cefaclor with pharmaceutically effective dose, pharmaceutically acceptable coating material, diluent, disintegrant, glidant, flavouring and lubricant. Ingredients, such as the coating material, the diluent, the disintegrant and the like, and contents are screened, and the preparation technology is improved by numerous studies by the applicant of the invention, thereby obtaining a prepared product with faster effect and more sufficient absorption. The tablet can be disintegrated or dissolved in more than ten seconds in an oral cavity by swallowing without drinking water. The tablet is more suitable for the elderly and patients with solid-swallowing difficulty, and provides great convenience for patients which are busy in work or can not take water conveniently.

Description

technical field

[0001] The invention relates to a cefaclor orally disintegrating tablet and a preparation method thereof, belonging to the technical field of medicine. Background technique

[0002] Cefaclor (cefaclor, CCL, cephalexin, trade names: Hikerao, Xindaro, Xin Ke Nuo, Shi Dagong, Kefule, Dafukang), the molecular formula is C 15 h 14 ClN 3 o 4 S·H 2 O, the structural formula is as follows:

[0003]

[0004] Cefaclor is a second generation oral cephalosporin antibiotic. It was developed by the United States in 1976, approved by the FDA in 1979, and launched in the United States in 1982. In 1985, it replaced cephalexin and became the world's first best-selling antibiotic. In February 1994, Cefaclor was introduced to the Chinese market under the trade name "Xindaro". Because of its outstanding advantages such as broad antibacterial spectrum, high efficiency, good oral absorption, wide tissue distribution, and mild adverse reactions, cefaclor has become an idea...

Images