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Pilose antler micro-shear transformation accessory ingredient interaction processing technique

A processing technology and micro-shear technology, applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems of small surface area of ​​materials, low dissolution rate of active ingredients, residual solvent pollution, etc., to achieve surface area increase Greatly improved effect

Active Publication Date: 2011-01-19
大连鹿成生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problems of small material surface area, low dissolution rate of functional components, low bioavailability of functional components, and pollution caused by solvent residues in the processing of velvet antler, so as to propose a method for increasing the surface area of ​​materials for velvet antler powder. , A new processing method to improve the dissolution rate of functional ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dry Ergang deer antler whole powder to absorb moisture to a moisture content of 13%;

[0020] The fineness of primary crushing passes through the 380μm sieve;

[0021] Add 2% sucrose and 3% sodium bicarbonate to the solid material and mix evenly;

[0022] Put into the planetary vibrating mill with steel balls, and micro-cut for 6 minutes with the aid of additives.

[0023] Under the microscope, the surface area of ​​each gram of material is 315cm 2 / g, the IGF-1 content reached 2.32μg / mg when dissolved in water for 30 minutes.

Embodiment 2

[0025] Dry the upper 1 / 3 part of Ergang deer antler until the moisture absorption reaches 10%;

[0026] The fineness of primary crushing passes through the 380μm sieve;

[0027] Add 2% sodium bicarbonate and 3% citric acid to the solid material and mix evenly;

[0028] Put into the planetary vibrating mill with steel balls, and micro-cut for 8 minutes with the aid of additives.

[0029] Under the microscope, the surface body of each gram of material is measured as 318cm 2 / g, the IGF-1 content reached 2.87μg / mg when dissolved in water for 30 minutes.

Embodiment 3

[0031] Dry the absorbed moisture in 1 / 3 part of Ergang velvet antler to 14%;

[0032] The fineness of primary crushing passes through the 380μm sieve;

[0033] Add 5% citric acid to the solid material and mix evenly;

[0034] Put into the planetary vibrating mill with steel balls, and micro-cut for 8 minutes with the aid of additives.

[0035] Under the microscope, the surface body of each gram of material is measured as 318cm 2 / g, the IGF-1 content reached 2.23μg / mg when dissolved in water for 30 minutes.

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PUM

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Abstract

A pilose antler micro-shear transformation accessory ingredient interaction processing technique comprises the steps as follows: firstly, the raw material of pilose antler is pretreated, the water ratio is required to be less than or equal to 14.0%, and the fineness of primary pulverization passes through a sieve pore with 380mum; neutral food grade chemical addition agent or acidic addition agent is added into solid materials based on the mass percent of 1-5%; a steel ball body planet vibrating mill with the shearing action is selected for use; the mixed material obtained in the second step is processed for 6-10min, so that maximum superficial area can be achieved. Compared with the existing technique for processing micro powder or submicron powder, the extent of superficial area increment is increased by eight times or more; the fineness reaches the level that materials pass through the sieve pore with 18 mum; and the dissolution rate of efficacy factor IGF-1 can be increased by 13.05-17.79 times.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a processing technology for increasing the surface area and effectively dissolving functional components in the processing of deer antler powder technical background [0002] Deer antler is the young horn of the unossified Yayoi hair of the male deer. It is one of the three treasures of Northeast China and the top grade of animal medicine in the treasure house of Chinese medicine. "Compendium of Materia Medica" contains: "The whole body of the sika deer is beneficial to people, whether it is steamed, boiled, or preserved, and it is good for eating with wine. Mostly the sika deer is a fairy beast, a thing of pure yang and longevity. , so its meat and horns are beneficial and harmless. It can be seen that eating sika deer products is not only a noble embodiment, but also a top-grade dietary pursuit. Since ancient times, my country has the concept of homology of medicine and food, so velv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/32
Inventor 刘成肖振铎刘志桐徐永平金礼吉
Owner 大连鹿成生物工程有限公司