Sulpho-glucosan derivative and preparation method and application thereof

A glucopyranoside and thiol technology, which can be used in sugar derivatives, metabolic diseases, drug combinations, etc., and can solve problems such as hepatotoxicity and body weight
CN101445528AInactive Publication Date: 2009-06-03TIANJIN INSTITUTE OF PHARMA RESEARCH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN INSTITUTE OF PHARMA RESEARCH
Publication Date
2009-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of diabetes related medicine, in particular to a depressor for a Na-glucose transporter II containing a structure of sulpho-glucose (SGLT2) and a preparation method thereof, and a pharmaceutical composition containing SGLT2 and an application thereof in the preparation of diabetes drugs, wherein, a radical group is defined in the specification.
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Description

technical field

[0001] The invention relates to the field of medicine related to diabetes. Specifically, the present invention relates to a sodium glucose transporter type 2 (SGLT2) inhibitor containing a glucosinolate structure, which has a therapeutic effect on diabetes, a preparation method thereof, and a pharmaceutical composition containing them. Background technique

[0002] There are currently about 170 million diabetics in the world, and the vast majority of them are type II (ie, non-insulin-dependent) diabetics. The antidiabetic drugs currently in clinical use mainly include metformin, sulfonylureas and insulin drugs. In recent years, thiazolidinedione drugs, α-glucosidase inhibitors and dipeptidyl peptidase-IV have also been listed on the market. Inhibitors etc. These drugs have good therapeutic effects, but there are safety problems in long-term treatment, such as liver toxicity and weight gain.

[0003] Sodium glucose transporter type 2 (SGLT2) is a new target...

Claims

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