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Anti-fatigue agent containing amino acid composition

An anti-fatigue agent and amino acid technology, applied in medical preparations containing active ingredients, drug combinations, food science, etc., can solve the problems of uncertain fatigue recovery and fatigue recovery, and achieve low capacity and high fatigue Preventive effect, preventive effect of muscle fatigue and nerve fatigue

Inactive Publication Date: 2009-06-10
MEIJI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after physical fatigue and mental fatigue, the fatigue cannot be recovered only by supplementing the above amino acids, and it is also uncertain whether the fatigue recovery effect can be obtained even if these amino acids are taken in advance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0117] Hereinafter, examples of the present invention are given and the present invention is described in detail, but the present invention is not limited to these specific examples.

[0118] Mice (male, 8-week-old, C57BL / 6N, light and dark at 23±3°C for 12 hours) were distributed as evenly as possible according to the body weight of each group, and divided into groups of 3-4 mice per group. Test group (embodiment) and control group (comparative example). The mice were not fasted, and were forcibly orally administered the anti-fatigue agent of the present invention or physiological saline used as a control agent. An exercise load was applied by treadmill exercise test (60 minutes at 25 m / min) 1 hour after the administration.

[0119] In addition, the dosage was 500 mg / kg body weight in terms of amino acid (administration of 5% suspoemulsion in an amount of 10 μL / g body weight). The amino acid composition of the anti-fatigue agent of the present invention administered therein...

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PUM

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Abstract

It is intended to provide an anti-fatigue agent capable of preventing both muscle fatigue and nerve fatigue simultaneously. According to the invention, both muscle fatigue and nerve fatigue can be simultaneously prevented with the anti-fatigue agent containing an amino acid composition comprising specific types and specific amounts of amino acids. With regard to preferred amino acid types and amount ratios, it is an amino acid composition containing 30 to 200 parts by weight of proline, 60 to 140 parts by weight of glycine, 25 to 260 parts by weight of alanine, 40 to 130 parts by weight of lysine, 20 to 75 parts by weight of tryptophan, and 15 to 40 parts by weight of histidine. Further, it preferably contains 35 to 65 parts by weight of threonine, 15 to 65 parts by weight of tyrosine, and 25 to 45 parts by weight of arginine, and further, it preferably contains 30 to 55 parts by weight of valine, 35 to 60 parts by weight of leucine, and 25 to 45 parts by weight of isoleucine.

Description

technical field [0001] The present invention relates to an anti-fatigue agent containing an amino acid composition composed of specific kinds of amino acids. Background technique [0002] For people living in modern society, the phenomenon of "fatigue" has gradually become a status quo that cannot be ignored. According to the survey results in recent years, nearly 60% of the people in the country have a sense of fatigue, and nearly 40% of them have a sense of fatigue that lasts for more than 6 months. If this is converted into the employed population, nearly 30 million workers are engaged in work with constant fatigue. In addition, in cases of severe chronic fatigue, it can interfere with daily life. Furthermore, the economic losses caused by these fatigues, including costs related to rehabilitation measures, can be estimated to be in the range of hundreds of billions of yen to one trillion yen. [0003] Fatigue can be broadly classified into acute fatigue and chronic fat...

Claims

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Application Information

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IPC IPC(8): A61K31/198A23L1/305A61K31/401A61K31/405A61K31/4172A61P3/02A61P43/00
CPCA23V2002/00A23L1/3051A61K31/4172A61K31/405A61K31/401A61K31/198A23L33/175A61P3/02A61P21/00A61P25/00A61P43/00A23V2200/316A23V2250/064A23V2250/0622A23V2250/0604A23V2250/063A23V2250/065A23V2250/0624A23V2250/0648A23V2250/0652A23V2250/0606A23V2250/0654A23V2250/0628A23V2250/0626A23V2200/322
Inventor 斎藤真人有田宏行土田博
Owner MEIJI CO LTD
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