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Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens

A technology of pathogens and agglutinating agents, which can be used in antiviral agents, metabolic diseases, and vector-borne diseases, and can solve problems such as heavy economic costs and high medical costs

Active Publication Date: 2013-01-16
NUTRITION SCI N V
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This tolerance proves fatal to thousands of people each year and results in high medical costs and heavy economic costs (Barton, 1998)

Method used

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  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens
  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens
  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Effects of trimannosaccharides and tetramannosaccharides on microbial ecology in the gastrointestinal tract of poultry system impact

[0049] 3 x 40 one-day-old chicks were provided with the following feeds: control feed, control feed supplemented with 3 ppm flavomycin, and control feed supplemented with 0.025% trimannosaccharide and / or tetramannooligosaccharide. The control feed was a mashed feed consisting of raw materials suitable as animal nutrition. Water and feed were provided ad libitum. Chicks were infested on day 2 with the contents of the cecum of three-week-old chicks (the period with the most severe gastrointestinal problems). Chicks were dissected at time intervals and the intestinal pathogen content in the small intestine was determined by plate counting on McFarland agar. The results are summarized in figure 1 middle.

[0050] from figure 1 It was clearly seen that trimannosaccharides and / or tetramannosaccharides had a positive effect ...

Embodiment 2

[0051] Example 2: Tri-galacturonic acid oligosaccharides and / or tetragalacturonic acid oligosaccharides (tri-and / or Effects of tetra-galacturonic-oligo-saccharide) on chick performance

[0052] The same experimental conditions as described in Experiment 1 were used. Daily growth and feed conversion were monitored after 13 days in this example. The results are summarized in Table 1.

[0053] Table 1: Effects of tetra-oligosaccharides on chick performance

[0054]

[0055] From Table 1 it can be concluded that the use of trigalacturonic acid oligosaccharides and / or tetragalacturonic acid oligosaccharides in this particular experiment gave similar results to those obtained with the traditional growth promoter (flavin). But the modes of action are not comparable (see Example 1).

Embodiment 3

[0056] Example 3: Trigalacturonic acid oligosaccharides and / or tetragalacturonic acid oligosaccharides on piglet performance Impact

[0057] At the beginning of the experiment, 5 piglets were housed in each pen. A feed trough (optionally assembled) was provided per pen for the administration of solid pellets. One drinking nipple per column. The temperature was started at 28°C until 10 days after weaning. The temperature was then lowered to 25°C. Administer a commercially available drug-free diet. Drug-free means that the piglets did not receive any therapeutic antibiotics before and during the experiment. The diet was administered in pellet form.

[0058] The diet is as follows:

[0059] -Co: Control diet

[0060] -Tr: Control diet + 0.125% mannooligosaccharide

[0061] The experimental design was as follows: 2 treatments (Co and Tr) × 16 parallel assays × 5 piglets.

[0062] At the beginning of the experiment, piglets (about 7 kg body weight) were distributed by ...

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Abstract

Compositions which include a homotrimer, heterotrimer, homotetramer, and / or heterotetramer of a component such as pentose, hexose, an L or D isomer of a pentose or hexose, a beta-form of a pentose or hexose, oxidized derivatives and mixtures of such compounds are disclosed as agglutination agents. The disclosed compositions are useful for agglutination of enteric pathogens and may be used for selectively controlling and regulating the microbial ecosystem in the gastrointestinal tract of a subject.

Description

technical field [0001] The present invention relates to the use of trioligosaccharides and tetraoligosaccharides or their extracts or their derivatives or their mixtures as pathogen agglutination agents (agglutination agent). In particular, the present invention relates to trioligosaccharides and tetraoligosaccharides or their extracts or their derivatives or mixtures thereof for the improvement of microbiological activity in the gastrointestinal tract of animals by specific enumeration and subsequent specific excretion of enteric pathogens The use of the ecosystem thus improves animal weight gain, reduces feed conversion and in this way improves animal feed value, health and well-being. Background technique [0002] In modern animal production systems, the balance between the intestinal microflora and the host animal is a delicate one, and disturbance of this balance (eg by bacterial infection) will negatively affect the overall performance of the animal (Eckel, 1999). Kno...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/702A61P31/00A61P1/12
CPCA61K31/702A23L29/30A23L33/30A61P1/00A61P1/12A61P31/00A61P31/04A61P31/12A61P3/04Y02A50/30
Inventor 格特·布吕热曼卡特林·德谢佩
Owner NUTRITION SCI N V
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