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Coptis root dispensing granule as well as preparation method and quality control method thereof

A technology of formula granules and Coptis chinensis, applied in the field of Coptis chinensis formula granules and its preparation, can solve problems such as difficulties in spectrum analysis

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the spectra, so that conventional infrared spectroscopy has not been able to play its due role in the quality control and management of traditional Chinese medicines for a long period of time. the role of

Method used

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  • Coptis root dispensing granule as well as preparation method and quality control method thereof
  • Coptis root dispensing granule as well as preparation method and quality control method thereof
  • Coptis root dispensing granule as well as preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Coptis chinensis formula granules

[0040] Take 100kg of Coptidis decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.05-1.10 The concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air delivery temperature is 45°C, and the spray drying is obtained to obtain Coptis chinensis spray-dried powder; Add the auxiliary material dextrin of its own weight portion 0-5% in the powder; Coptis chinensis spray-dried powder is under the condition that the pressure of the main pressure wheel is 5MPa, the pressure of the side pressure wheel is 0.5MPa, the spindle speed is 400 rpm, and the feeding voltage is 120V. Dry granu...

Embodiment 2

[0041] Example 2: Coptis chinensis formula granules

[0042] Take 100kg of Coptidis decoction pieces, add 1000kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.00-1.05 The concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray drying is obtained to obtain Coptidis Coptidis spray-dried powder; Add 5-15% of its own weight of auxiliary material dextrin to the powder; dry granulation under the conditions of main pressure roller pressure 6MPa, side pressure roller pressure 0.4MPa, spindle speed 450 rpm, and feeding voltage 110V , to get 20-60 mesh Coptidis formula granules, each gram of Coptidis formula granules...

Embodiment 3

[0044] Example 3: Coptis rhizome formula granules

[0045] Take 100kg of Coptis decoction pieces, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10-1.15 The concentrated solution is preheated at 45°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray drying is obtained to obtain Coptis chinensis spray-dried powder; Add the lactose of its own weight portion 15-25% in the powder; Dry granulation under the condition that the main pressure wheel pressure is 4MPa, the side pressure wheel pressure is 0.4MPa, the spindle speed is 500 rev / min, and the feeding voltage is 130V, to obtain 20-60 mesh Coptidis formula granules, each gram of Coptidis fo...

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Abstract

The invention discloses a rhizoma coptidis formula particle and preparation and quality control methods thereof. The formula particle is made from rhizoma coptidis decoction pieces used as raw materials, and the decoction pieces are processed by the technological processes of two times of water extraction, depressurization, concentration, spraying, drying, and the like to gain the rhizoma coptidis formula particle; and one gram of rhizoma coptidis formula particle is equivalent to 5 to 10 gram of crude medicines, wherein, the content of berberine hydrochloride is not lower than 6 percent. The quality of the rhizoma coptidis decoction pieces and the quality of the rhizoma coptidis formula particle are respectively discriminated by the infrared fingerprint spectra. The rhizoma coptidis formula particle of the invention has the advantages of integrated and advanced production process, high special and controllable quality control standard and advanced and realizable process, and a test method for the quality standard is scientific, advanced, fast and highly practical. As Proven by experiments, the ingredient of a herbal decoction prepared by the rhizoma coptidis formula particle of the invention is equivalent to the ingredient of a rhizoma coptidis contained classic formula co-decoction, the full ingredient formula particle process is achieved, and the process of the invention is proven to be reasonable; and the invention applies the infrared spectra technology to the quality control of the traditional Chinese medicine, thereby fast solving the principle problem of traditional Chinese medicine discrimination in the macroscopical quality control of the traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule, a preparation method and a quality control method thereof, in particular to a Coptis chinensis formula granule, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA