Coenzyme Q10 intravenous transfusion and preparation method thereof

Abstract

The invention discloses coenzyme Q10 venous transfusion preparation and a preparation method thereof. The prior coenzyme Q10 venous transfusion adopts polysorbate 80 or the composite of the polysorbate and other materials as a solubilizer which is excipient with potential hazard and causes the large influence to the health of people when being misemployed. The preparation method comprises the following steps: firstly, injection solvent is added after coenzyme Q10 and polyethylene hydroxyl stearate solubilizer are mixed and heated until molten so as to enable the mixture to become transparent solution, an osmotic pressure regulator is added for removing a heat resource, and the venous transfusion preparation according with the injection requirement is made by the procedures of constant volume, filtering and packaging. The invention greatly improves the stability as well as the application level and the safety of the coenzyme Q10 venous transfusion preparation.

Description

technical field [0001] The present invention relates to the field of biochemical medicine, especially a kind of coenzyme Q 10 Intravenous infusion and its preparation method. Background technique [0002] coenzyme Q 10 , also known as "ubiquinone", is a fat-soluble natural vitamin substance commonly found in many organisms, and is a coenzyme for mitochondrial oxidative phosphorylation. coenzyme Q 10 It is a multifunctional biochemical drug, which has natural anti-oxidation and cell metabolism activation effects, and can significantly improve human immunity. The drug is mainly used clinically for cardiovascular diseases, scurvy, aplastic anemia, duodenal ulcer , Acute and chronic viral hepatitis, subacute hepatic necrosis, congestive heart disease, emphysema and other diseases, as well as adjuvant therapy for cancer patients, has broad clinical application prospects. [0003] coenzyme Q 10 Very easily soluble in chloroform and benzene, easily soluble in acetone and ether...

AI Technical Summary

Problems solved by technology

Therefore, the use of polysorbate 80 (Tween 80) has strict restrictions. It is a potentially unsafe auxiliary material, and improper use will have a great impact on people's health

[0009] In addition, the investigation results of adverse reaction events of Houttuynia cordata injection confirmed that by analyzing 19 batches of Houttuynia cordata injection from 9 enterprises, it was found that the content of polysorbate 80 (Tween 80) was 0.07% to 0.59%. The difference is 8 times, and there is a certain randomness in the addition of polysorbate 80 (Tween 80) in Houttuynia cordata injection

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