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Traditional Chinese medicine soft-capsule and preparation method thereof

A technology of soft capsules and traditional Chinese medicines, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as poor efficacy, reduce penetration, improve disintegration time limit, and slow down oxidation by oxygen Effect

Active Publication Date: 2011-08-03
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the past, a certain amount of beeswax was often added, but the effect was still not good, and it could not solve the problem of aging of soft capsule materials

Method used

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  • Traditional Chinese medicine soft-capsule and preparation method thereof
  • Traditional Chinese medicine soft-capsule and preparation method thereof
  • Traditional Chinese medicine soft-capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Duyiwei Soft Capsules

[0064] Capsule formula:

[0065] Gelatin 100kg Glycerin 30kg

[0066] Liquid sorbitol 7.5kg Water 80kg

[0067] Fumaric acid 1kg Cysteine ​​1kg

[0068] Ethyl Paraben 0.1kg Chocolate Brown 0.5kg

[0069] Titanium dioxide 1kg

[0070] Contents recipe:

[0071] Duyiwei Extract Powder 100kg Polyethylene Glycol 400 200kg

[0072] Fumaric acid 3kg Cysteine ​​3kg

[0073] Lecithin 6kg;

[0074] Get the above raw materials and make soft capsules according to conventional techniques.

Embodiment 2

[0075] Embodiment 2: Duyiwei Soft Capsules

[0076] Capsule formula:

[0077] Gelatin 100kg Glycerin 25kg

[0078] Liquid sorbitol 15kg Water 80kg

[0079] Glycine 1kg Cysteine ​​1kg

[0080] Ethyl Paraben 0.1kg Chocolate Brown 0.5kg

[0081] Titanium dioxide 1kg

[0082] Contents recipe:

[0083] Duyiwei Extract Powder 100kg Polyethylene Glycol 400 200kg

[0084] Glycine 3kg Cysteine ​​3kg

[0085] Lecithin 6kg;

[0086] Get the above raw materials and make soft capsules according to conventional techniques.

Embodiment 3

[0087] Embodiment 3: Jingangteng Soft Capsule

[0088] Capsule formula:

[0089] Gelatin 100kg Glycerin 25kg

[0090] Liquid sorbitol 15kg Water 80kg

[0091] Glycine 1kg Cysteine ​​1kg

[0092] Ethyl Paraben 0.1kg Chocolate Brown 0.5kg

[0093] Titanium dioxide 1kg

[0094] Contents recipe:

[0095] King Kong Rattan Extract Powder 40kg Soybean Oil 55kg

[0096] Glycine 1kg Cysteine ​​1kg

[0097] Beeswax 0.25kg Lecithin 1kg

[0098] Get the above raw materials and make soft capsules according to conventional techniques.

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PUM

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Abstract

The invention discloses a soft capsule preparation for a traditional Chinese medicine extract and a preparation method thereof. The soft capsule consists of a capsule material and content, wherein in the preparation process of the capsule material, trans-butene diacid, liquid sorbierite and cysteine are added into the capsule material simultaneously; the trans-butene diacid, the systeine and lecithin are added into the content; the trans-butene diacid can be replaced by glycin or citric acid; and the systeine can be replaced by sodium metabisulfite or sodium sulfite, and is added with conventional auxiliary materials to prepare the soft capsule according to the prior art. Experiments prove that disintegration time limit of the soft capsule is significantly improved; and compared with the prior art, the capsule and the method obviously prolong the aging of the capsule material of the soft capsule.

Description

technical field [0001] The invention relates to a soft capsule and a preparation method thereof, in particular to a traditional Chinese medicine soft capsule and a preparation method thereof. Background technique [0002] In the prior art, the content of traditional Chinese medicine soft capsules generally contains aldehydes, which can chemically react with the gelatin in the soft capsule material, resulting in an increase in the degree of crosslinking of the gelatin, denaturation and hardening of the gelatin, resulting in Disintegration failed. Gelatin is oxidized by oxygen to undergo a cross-linking reaction, resulting in an increase in the degree of cross-linking of gelatin, and can also denature and harden gelatin, resulting in unqualified disintegration. In addition, the contents of traditional Chinese medicine soft capsules are prone to stratification during storage. After stratification, the Chinese medicine extract part is fully in contact with the capsule material,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K36/00A61K36/53A61K36/896A61K36/28A61K47/42A61K47/12A61K47/20A61K47/10A61K47/34A61K47/24
Inventor 罗琴胡思玉谭兴根李转花王利春梁隆程志鹏
Owner SICHUAN KELUN PHARMA CO LTD