Automatic measuring and analyzing method based on machine visual flu vaccine hemagglutinin content

Abstract

The invention relates to an automatic measuring and analyzing method based on the machine visual flu vaccine hemagglutinin content. A full-automatic measuring process without human interference is used. Images of single-direction radiating immunodiffusion can be eternally stored. The measuring process is not interfered by background light and a person, and the irregular diffusion of a solution orthe noise of a glass plate can be excellently processed. The integrative analysis and statistic optimal calculation of data is carried out in a data analyzing system, the automatic stable-bond fittingof the solution is standard, the standard relevant coefficients of the solution are given out, the standard confidence interval of the solution is determined, and the processing and detection algorithm of sub-pixel-grade images is used for a diffusion ring. The detection of the original data and the analysis of the electronic filing of a data diagram can be automatically realized, meanwhile, detection reports containing different lot-number combination are outputted as required to realize the full-automatic measuring and analyzing process of the hemagglutinin content to precisely detect the entire quality of the flue vaccine, the precision is higher than 2 micrograms / ml, and the stability of the measuring system is from -5 percent to +5 percent.

Description

Technical field [0001] The invention is an automatic measurement and analysis method for the hemagglutinin content of influenza vaccine based on machine vision. Background technique [0002] Influenza (flu) refers to an acute respiratory infectious disease with a high infection rate caused by an influenza virus (Influenza Virus), and high morbidity and mortality occur worldwide every year. Influenza virus is highly contagious and spreads by respiratory droplets, which can easily cause epidemics. Infants, young children, the elderly and the infirm often have secondary bacterial infections in the late stages of influenza. At present, there is no specific treatment for influenza, and immunization with influenza vaccine is the most effective way to prevent influenza. Influenza vaccine can effectively prevent influenza. Hemagglutinin is an effective immune substance in the vaccine. It is the main antigen on the surface of influenza virus particles and is an important item in vaccine q...

AI Technical Summary

Problems solved by technology

The accuracy of this method is mainly determined by the accuracy of the scanner, and there is no way to accurately control the accuracy of the ferrule diffusion ring, and the measurement of the diffusion ring is still manually measured, so human errors are inevitable in the measurement process

So far, the automatic measurement and analysis method of influenza vaccine hemagglutinin content based on machine vision has not been reported

Images