Automatic measuring and analyzing method based on machine visual flu vaccine hemagglutinin content

An influenza vaccine and analysis method technology, which is applied in the field of automatic measurement and analysis of the hemagglutinin content of influenza vaccines based on machine vision, can solve the problems such as the automatic measurement and analysis method has not been reported, and the accuracy of the ferrule diffusion ring cannot be accurately controlled. , to achieve the effect of accurate detection and improvement of overall quality

Inactive Publication Date: 2009-09-02
CHANGCHUN UNIV OF SCI & TECH
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Problems solved by technology

The accuracy of this method is mainly determined by the accuracy of the scanner, and there is no way to accurately control the accuracy of the ferrule diffusion ring, and the measurement of the diffusion ring is still

Method used

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  • Automatic measuring and analyzing method based on machine visual flu vaccine hemagglutinin content
  • Automatic measuring and analyzing method based on machine visual flu vaccine hemagglutinin content
  • Automatic measuring and analyzing method based on machine visual flu vaccine hemagglutinin content

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Embodiment 1

[0038] Such as figure 1 As shown, the device used in the automatic measurement and analysis method of the hemagglutinin content of the influenza vaccine based on machine vision includes a glass plate 1, a light source 2, a lens 3, a camera 4, an image capture card 5 and a computer 6. The glass plate 1 , The light source 2, the lens 3, the camera 4 and the image capture card 5 constitute the diffusion circle image acquisition unit 10, and the computer 6 and the test analysis software stored in the computer 6 constitute the hemagglutinin content measurement and analysis unit;

[0039] Such as figure 1 As shown, a glass plate 1 is placed on the platform, and the pillar is fixedly connected to the platform and perpendicular to the platform. Above the glass plate 1, the light source 2, the lens 3, and the camera 4 are fixed on the pillar in turn from bottom to top, the light source 2, the lens 3 The height and horizontal angle of the camera 4 and the camera 4 can be adjusted by the k...

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Abstract

The invention relates to an automatic measuring and analyzing method based on the machine visual flu vaccine hemagglutinin content. A full-automatic measuring process without human interference is used. Images of single-direction radiating immunodiffusion can be eternally stored. The measuring process is not interfered by background light and a person, and the irregular diffusion of a solution orthe noise of a glass plate can be excellently processed. The integrative analysis and statistic optimal calculation of data is carried out in a data analyzing system, the automatic stable-bond fittingof the solution is standard, the standard relevant coefficients of the solution are given out, the standard confidence interval of the solution is determined, and the processing and detection algorithm of sub-pixel-grade images is used for a diffusion ring. The detection of the original data and the analysis of the electronic filing of a data diagram can be automatically realized, meanwhile, detection reports containing different lot-number combination are outputted as required to realize the full-automatic measuring and analyzing process of the hemagglutinin content to precisely detect the entire quality of the flue vaccine, the precision is higher than 2 micrograms /ml, and the stability of the measuring system is from -5 percent to +5 percent.

Description

Technical field [0001] The invention is an automatic measurement and analysis method for the hemagglutinin content of influenza vaccine based on machine vision. Background technique [0002] Influenza (flu) refers to an acute respiratory infectious disease with a high infection rate caused by an influenza virus (Influenza Virus), and high morbidity and mortality occur worldwide every year. Influenza virus is highly contagious and spreads by respiratory droplets, which can easily cause epidemics. Infants, young children, the elderly and the infirm often have secondary bacterial infections in the late stages of influenza. At present, there is no specific treatment for influenza, and immunization with influenza vaccine is the most effective way to prevent influenza. Influenza vaccine can effectively prevent influenza. Hemagglutinin is an effective immune substance in the vaccine. It is the main antigen on the surface of influenza virus particles and is an important item in vaccine q...

Claims

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Application Information

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IPC IPC(8): G01N33/558G06T1/00G06T7/00
Inventor 景文博王晓曼董绍捷段锦杨文波祝勇付强姜会林
Owner CHANGCHUN UNIV OF SCI & TECH
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