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Co-production process for extracting multiple bioactive substances from pig placenta

A bioactive substance, pig placenta technology, applied in biochemical equipment and methods, anti-animal/human immunoglobulin, peptide preparation methods, etc., can solve problems such as short supply, reduce production costs, improve economic benefits, low cost effect

Active Publication Date: 2011-11-30
ZHENGZHOU NUBLION BIOTECH
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  • Abstract
  • Description
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Problems solved by technology

At the same time, immunoglobulin can also be used as a feed additive for young animals, especially in intensive breeding bases. Applying immunoglobulin to early weaned young animals can reduce diseases of young animals and promote growth and development. Currently, the animal feed additive market is in short supply.

Method used

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  • Co-production process for extracting multiple bioactive substances from pig placenta
  • Co-production process for extracting multiple bioactive substances from pig placenta

Examples

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Embodiment Construction

[0038] The present invention will further describe the specific operation steps below in conjunction with the accompanying drawings:

[0039] 1. Collect the fresh placenta (including piglet blood) within 24 hours after delivery and weigh it. Cut the fetal membranes and umbilical cord, add 2% sodium chloride water of equal weight and volume and soak for about 1 hour, pulverize with a meat grinder, then soak for more than about 1 hour, coarse filter (20 mesh), collect the filtrate (I) respectively and filter residue (I).

[0040] 2. The filtrate was centrifuged (3000 rpm) for 20 minutes, and the supernatant (I) and red precipitate were collected. Add an equal volume of deionized water to the red precipitate, stir for 30 minutes to fully hemolyze the red blood cells, then add ammonium sulfate by volume to 50% saturation, stir for 30 minutes, let stand for 2 hours, and centrifuge. Measure the volume of the centrifuged supernatant, add 0.15 times the volume of ethanol and 0.08 ti...

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Abstract

The invention provides a coproduction process for extracting various bioactivators from pig placenta, which comprises the following steps: taking the pig placenta (containing farrowing blood) as a raw material, utilizing components rich in the raw material such as immune globulin (Ig), immunocompetent peptide, superoxide dismutase (SOD), lipopolysaccharide, placental protein and the like, and applying modern biochemistry technology and biological integration technology such as salting in, salting out, chromatography, ultra-filtration and the like according to different structures, molecular weights, isoelectric points, physical and chemical properties, biological activities of the components to make the coproduction process suitable for industrial production. Therefore, in the same flow of the production process, the effective components in the pig placenta with market development value can be produced, namely five products of the immune globulin, the immunocompetent peptide, the superoxide dismutase, the lipopolysaccharide and the placental protein. The process combines the conventional and modern processes, produces various products through coproduction, and not only makes full use of placenta resources to change the waste into the treasure, does not discharge waste liquid and prevents the environment, but also can greatly reduce the production cost and improve the economic benefit.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a co-production process for the comprehensive utilization of pig placenta (including blood production), which uses pig placenta as the main raw material and applies modern biological process integration technology. In the same production process, immune Globulin (Ig), immune active peptide, superoxide dismutase (SOD), lipopolysaccharide, placental protein, a total of 5 series of products, can be widely used in medicine, health care, daily chemical industry and animal husbandry. Background technique [0002] Humans have a long history of using the placenta. About 400 years ago, Li Shizhen, in his "Compendium of Materia Medica", which collected the culmination of ancient and modern Chinese medicine, believed that the placenta of humans, sheep, pigs, cattle and other mammals could be used as medicine, and named the placenta "Ziheche". Modern science has proved that the placenta contain...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N9/08C07K16/18C07K14/47C07K1/14C12P21/06C08B37/00
Inventor 常功张俊英王景仙
Owner ZHENGZHOU NUBLION BIOTECH
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