Solid pharmaceutical composition containing repaglinide

A technology of composition and medicine, which is applied in the field of solid pharmaceutical composition, can solve the problems of slow onset of action and achieve the effect of fast onset of action and high compliance

Active Publication Date: 2009-10-07
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pharmaceutical composition it protects can only be dissolved within 30 minutes, and the onset of action is slow

Method used

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  • Solid pharmaceutical composition containing repaglinide
  • Solid pharmaceutical composition containing repaglinide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: It exists in the form of orally disintegrating tablet

[0017]

[0018] Preparation process: Weigh repaglinide, microcrystalline cellulose, sorbitol and low-substituted hypromellose sodium according to the prescription, mix them evenly, use shallow concave punching tablets with a diameter of 12mm, crush them, pass through a 30-mesh sieve for granulation , add orange essence and magnesium stearate, mix well, and compress into tablets.

Embodiment 2

[0019] Embodiment 2: It exists in the form of dispersible tablets

[0020]

[0021] Preparation process: take repaglinide according to the prescription quantity, weigh the other auxiliary materials except green apple powder essence and magnesium stearate in the prescription quantity, pass through 80 mesh, mix well, add 50% alcohol aqueous solution as adhesive, Make soft material, pass through a 20-mesh sieve to granulate, dry, and granulate with a 24-mesh sieve; add magnesium stearate and green apple essence in the prescribed ratio, mix well, and compress into tablets.

[0022] The sample dissolution rate that embodiment 1 and embodiment 2 make sees the table below:

[0023] Example 1 and Example 2 sample dissolution table

[0024] 5min

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Abstract

The invention discloses a solid pharmaceutical composition containing repaglinide. The solid pharmaceutical composition can exist in various forms of dispersing tablets, oral disintegrating tablets and capsules and is used for curing the type 2 diabetes of which the high blood sugar cannot be effectively controlled by diet control and exercise.

Description

technical field [0001] The invention relates to a solid pharmaceutical composition containing repaglinide, in particular to a solid pharmaceutical composition of repaglinide for treating type 2 diabetes whose hyperglycemia cannot be effectively controlled by diet control and exercise. Background technique [0002] Repaglinide is a non-sulfonylurea insulin-stimulating agent. This product specifically binds to the 36KDA protein on the ATP-dependent potassium ion channel outside the islet cell membrane, closing the potassium channel, opening the calcium channel, and influx of calcium ions. , to promote insulin secretion, its effect is faster than sulfonylureas, so the postprandial hypoglycemic effect is faster. This product is mainly used for patients with type 2 diabetes whose hyperglycemia cannot be effectively controlled by diet control and exercise. [0003] WO0121159 discloses a combined drug of repaglinide or nateglinide and other drugs for treating diabetes, which is us...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K9/20A61P3/10
Inventor 孟凡静
Owner AVENTIS PHARMA HAINAN
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