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Granular niacin production method by extrusion and granulation

An extrusion granulation and granulation technology, which is applied in the extrusion and granulation of raw materials, organic chemistry, etc., can solve the problems of difficult reprocessing for users, easy product agglomeration and agglomeration, and harsh environment, so as to avoid agglomeration, agglomeration and dust. Contamination problems, ease of processing, avoiding the effect of excessive particle size

Inactive Publication Date: 2009-10-28
HANGZHOU SHENGDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The biggest disadvantage of using this process is that the obtained product is powdery, and its particle size is very small, below 0.1mm
Due to the small particle size, the product has a lot of dust during packaging and use, and the environment is harsh, and the product is easy to agglomerate and agglomerate during storage and transportation, which makes it difficult for users to reprocess

Method used

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  • Granular niacin production method by extrusion and granulation

Examples

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Effect test

Embodiment 1

[0018] refer to figure 1 , a method for producing nicotinic acid granules by extrusion granulation, the method steps comprising:

[0019] 1. Hopper lifting and metering: the niacin powder raw material is lifted to the high-level metering tank (2) through the hopper elevator (1);

[0020] 2. Tablet compression: Send the metered niacin powder into the tablet press (3) for tablet compression. The pressure for tablet compression is 15MPa; the thickness of the powder for tablet compression is 1.0mm;

[0021] 3. Crushing: send the product obtained by tableting to the crusher (4) for crushing, and the crushing particle size is 0.1~2.0mm;

[0022] 4. Screening: The crushed product is sent to the sieve (5), which is divided into three layers, including two layers of screens, and the sieve residue on the top screen is large particles with a particle size > 0.8mm, this part of the product returns to the crusher (4); the particle size of the bottom layer of product is <0.2mm, returns to...

Embodiment 2

[0024] refer to figure 1 , a method for producing isonicotinic acid granules by extrusion granulation, the method steps comprising:

[0025] 1. Hopper lifting and metering: the raw material of isonicotinic acid powder is lifted to the high-level metering tank (2) through the hopper elevator (1);

[0026] 2. Tablet compression: send the metered isonicotinic acid powder into the tablet press (3) for tablet compression. The pressure for tablet compression is 15MPa; the thickness of the powder for compression is 1.0mm;

[0027] 3. Crushing: send the product obtained by tableting to the crusher (4) for crushing, and the crushing particle size is 0.1~2.0mm;

[0028] 4. Screening: The crushed product is sent to the sieve (5), which is divided into three layers, including two layers of screens, and the sieve residue on the top screen is large particles with a particle size > 0.8mm, this part of the product returns to the crusher (4); the bottom layer of product particle size <0.2mm,...

Embodiment 3

[0030] According to the production process steps in Example 1, the production capacity of niacin / isonicotinic acid extrusion granulation can reach 200 kg / hour, the product mesh is between 30-70 mesh, and the product does not need to be further dried, and can be directly packaged. The photo of the powder product is shown in Figure 2, and the product after granulation is shown in Figure 3.

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Abstract

The invention provides a production method of niacin / isonicotinic acid granules by extrusion and granulation, comprising the following steps: lifting a hopper to a measuring tank and measuring the materials in the hopper and tabletting the materials in a tablet machine, crushing, screening the tablets to obtain the granular niacin / isonicotinic acid product with grain size of 0.2-0.8mm, respectively returning the over-large or over-small granules into the crushing and measuring step. The niacin / isonicotinic acid granules prevents the defects of the niacin / isonicotinic acid powder produced by the prior production method such as severe dust pollution of package, application place due to over-small grain size and grains cluster phenomena in storage and transportation and provides the convenience for the use of the niacin / isonicotinic acid granules as additives.

Description

technical field [0001] The invention provides a production method for producing granular niacin / isonicotinic acid through extrusion granulation, which belongs to the field of fine chemical industry. Background technique [0002] The English name of niacin is nicotinic acid, also known as 3-picolinic acid, nicotine acid, commonly known as vitamin B3, colorless needle-shaped crystals, belonging to the vitamin B group, is a pharmaceutical intermediate and feed additive, it is widely used in medicine, food And feed industry, but also used in dyestuffs and additives in daily chemical industry. The English name of isonicotinic acid is Isonicotinic acid, also known as 4-pyridinecarboxylic acid, isonicotinic acid, colorless needle-like crystal, is a widely used intermediate, mainly as isoniazid (remifen), terfenadine It can also be used as the raw material of first-line anti-tuberculosis drugs such as isonicotinate, anti-corrosion agent, electroplating additive, photosensitive resi...

Claims

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Application Information

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IPC IPC(8): C07D213/80C07D213/79B01J2/20
Inventor 姜木根陈银飞卢晗锋
Owner HANGZHOU SHENGDA PHARMA
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