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Application of iridoid compound in preparation of medicine for treating benign prostatic hyperplasia

A technology for benign prostatic hyperplasia and iridoids, applied in drug combinations, pharmaceutical formulas, organic active ingredients, etc., can solve problems affecting clinical and marketing, restricting the use of the elderly, and high prices

Active Publication Date: 2011-12-21
成都草木金华科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that it has a certain impact on a small number of cardiovascular patients, which limits the use of some elderly people and affects clinical and marketing promotion.
[0009] Most of the above-mentioned drugs have certain toxic and side effects, and the price is relatively high.

Method used

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  • Application of iridoid compound in preparation of medicine for treating benign prostatic hyperplasia
  • Application of iridoid compound in preparation of medicine for treating benign prostatic hyperplasia
  • Application of iridoid compound in preparation of medicine for treating benign prostatic hyperplasia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1 Preparation and structure identification of the compound of the present invention

[0069] 1. Extraction and separation

[0070] The coarse powder of spider odor rhizome (6kg) was extracted by percolation with 95% ethanol as the solvent, 30L of percolate was collected, and concentrated under reduced pressure to obtain 1500g of total extract. The total extract was dispersed in 500ml of water, and then extracted with petroleum ether (60~90℃), ethyl acetate and n-butanol. After the solvent was recovered under reduced pressure, 290g of petroleum ether (60~90℃) extract was obtained, which was extracted with ethyl acetate. 130g, 200g n-butanol extract.

[0071] (1) Further separation of petroleum ether extract

[0072] 100g of petroleum ether (60-90°C) extract was subjected to silica gel column chromatography (petroleum ether→petroleum ether / ethyl acetate→ethyl acetate→acetone gradient elution), and crudely divided into 204 parts.

[0073] PE51 # ~65 # After the samples wer...

Embodiment 2

[0099] Example 2 Preparation of an anti-benign prostatic hyperplasia capsule:

[0100] Take 1kg of compound A and 6kg of compound B, add an appropriate amount of starch, mix uniformly, dry granulate, sizing and sizing into capsules to obtain.

[0101] The following activity test proves the beneficial effects of the present invention.

experiment example 2

[0105] Experimental Example 2 Compound B of the present invention (PE116 # ) Inhibition of 5α-reductase activity

[0106] The experiment method is the same as experiment example 1.

[0107]

[0108]

[0109] The result shows that the sample PE116 # Shows positive, with clear activity.

[0110] The above results show that the petroleum ether part, the ethyl acetate part and the two monomer structure (compound A and compound B) components significantly inhibit the formation of DHT.

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Abstract

The invention discloses an application of an iridoid compound in preparing a medicine for treating benign prostatic hyperplasia. These compounds are derived from plants of the family Paterraceae. The medicinal use of plants of the Paternaceae family has a long history and is safe. The compound of the present invention has clearer medicinal substances than the original spider incense plant extract, and provides the possibility for preparing a new anti-benign prostatic hyperplasia drug with good market prospect.

Description

Technical field [0001] The present invention relates to a new use of a class of compounds, in particular, the use of iridoid compounds in the preparation of medicines for treating benign prostatic hyperplasia, and belongs to the field of medicines. Background technique [0002] With the acceleration of the aging process of society, the incidence of many elderly diseases has gradually increased. Among them, male prostate hyperplasia is one of the common diseases with a high probability of occurrence. According to statistical analysis, patients with benign prostatic hyperplasia (BPH) account for about 20% of elderly men. The incidence is also related to race and region. The incidence of Orientals is lower than that of Western ethnicities, and the incidence of BPH in foreign countries is significantly higher than that in China. Generally, the incidence rate in people with a family history of prostate hyperplasia is relatively high, accounting for more than 1 / 2. [0003] Studies ove...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P13/08
Inventor 肖丹边燕红
Owner 成都草木金华科技有限公司