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Preparing method of preparation for preventing and treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and preparations, which is applied in the field of preparation of preparations, can solve the problems of increasing the difficulty of developing a drug, difficulty in research time and funding, and complex components, and achieves the effects of significant blood viscosity, significant effect, and obvious effect.

Inactive Publication Date: 2011-05-25
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are also reports in the above-mentioned prior art that photosynthetic bacteria transform Chinese herbal medicines to prepare medicines, but the Chinese herbal medicines used are all compound prescriptions. The most important thing to develop modern Chinese medicines from Chinese medicine compound recipes is to go through prescription analysis, prescription research, and establishment of quality standards. From research time and funds There are great difficulties on the surface, not to mention the transformation with photosynthetic bacteria, the composition will be more complicated, which increases the difficulty of developing into drugs, and there is no chemical composition description in its patent report

Method used

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  • Preparing method of preparation for preventing and treating cardiovascular and cerebrovascular diseases
  • Preparing method of preparation for preventing and treating cardiovascular and cerebrovascular diseases
  • Preparing method of preparation for preventing and treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0052] Adopt following photosynthetic bacteria culture medium, its formula is:

[0053] Sodium acetate 1000-2000mg CaCl 2 .2H 2 O 50-100mg

[0054] MgSO 4 .7H 2 O 100-300mg EDTA 10-30mg

[0055] Yeast extract 500-1500mg K 2 HPO 4 500-1500mg

[0056] (NH 4 ) 2 SO 4 1000-2000mgKH 2 PO 4 400-1000mg

[0057] FeSO 4 .7H 2 O 5-15mg trace element solution 1-5ml

[0058] Deionized water 1000-2000ml pH 6-8

[0059] Wherein the trace element solution consists of:

[0060] h 3 BO 3 200-300mgNa 2 MoO 4 .2H 2 O 50-100mg

[0061] CuSO 4 2-10mg MnSO 4 .4H 2 O 150-250mg

[0062] ZnSO 4 .7H 2 O 20-30mg Deionized water 100-200ml

[0063] Insert 1 / 10 of the photosynthetic bacteria species into the photosynthetic bacteria culture medium, and cultivate them for 3 days under the light condition of 1000 Lux, as the photosynthetic bacteria seed culture solution.

[0064] Roots and rhizomes of Salvia miltiorrhiza Bge, dried naturally and ...

Embodiment 2

[0067] The preparation method of photosynthetic bacteria culture medium is the same as embodiment 1.

[0068] Insert 1 / 10 of the photosynthetic bacteria species into the photosynthetic bacteria culture medium, and cultivate them for 5 days under the light condition of 1000 Lux, as the photosynthetic bacteria seed culture solution.

[0069] Roots and rhizomes of Salvia miltiorrhiza Bge, dried naturally and crushed. 125 g of crushed salvia miltiorrhiza powder is extracted 4 times with 20% ethanol with 35 times the mass of salvia miltiorrhiza and a volume of 4375 ml, each extraction is 1 hour, the filtrate is combined, the ethanol in the extract is recovered under reduced pressure, concentrated until no alcohol smell, and alcohol extraction is obtained The filter residue was extracted with water for 3 times for 1 hour to obtain the water extract, which was combined with the alcohol extract to obtain the Salvia miltiorrhiza extract. Concentrate the salvia miltiorrhiza extract to ...

Embodiment 3

[0072] The preparation method of photosynthetic bacteria culture medium is the same as embodiment 1.

[0073] Insert 1 / 10 of the photosynthetic bacteria species into the photosynthetic bacteria culture medium, and cultivate them for 4 days under the light condition of 1000 Lux, as the photosynthetic bacteria seed culture solution.

[0074] Roots and rhizomes of Salvia miltiorrhiza Bge, dried naturally and crushed. 125 g of pulverized Danshen coarse powder is extracted twice with 40% ethanol with 15 times the weight of Danshen and a volume of 1875 ml, each time for 0.8 hours, the filtrates are combined, the ethanol in the extract is recovered under reduced pressure, concentrated until it has no alcohol smell, and alcohol extraction is obtained The filter residue was extracted twice with water for 0.8 hours to obtain the water extract and the alcohol extract to obtain the salvia miltiorrhiza extract. The salvia miltiorrhiza extract was diluted with water to a volume of 7 times ...

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Abstract

The invention discloses a preparing method of preparation for preventing and treating cardiovascular and cerebrovascular diseases. In the method, photosynthetic bacteria seed culture fluid is inoculated into alcohol extract or water extract of salvia miltiorrhiza according to the volume ratio of 1-5:10, and mixture is cultivated for 5 to 30 days under the condition of 500 to 3000 Lux illuminationand anaerobism so as to prepare photosynthetic bacteria converting salvia miltiorrhiza culture fluid; then, the photosynthetic bacteria converting salvia miltiorrhiza culture fluid is centrifugated atthe speed of 2000-7000r / min; supernatant fluid passes through a macropore polymeric adsorbent column to be firstly washed with water and then eluted with alcohol, and alcohol eluent is collected so as to obtain supernatant fluid alcohol eluent; precipitate is extracted for one to five times by alcohol liquid or refluence so as to obtain precipitate alcohol extract; the precipitate alcohol extractis combined with the supernatant fluid alcohol eluent, then the mixture is concentrated, and different oral preparations are prepared. The method has the advantages of simple production, obvious function of lowering blood fat and blood viscosity, easy absorption, high bioavailability and high content of active ingredients, and can be used for preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention relates to a method for preparing a preparation for preventing and treating cardiovascular and cerebrovascular diseases, in particular to a method for preparing a preparation for preventing and treating cardiovascular and cerebrovascular diseases by co-fermenting photosynthetic bacteria culture solution and Chinese herbal medicine extract. Background technique [0002] Photosynthetic bacteria (PSB) are prokaryotic ancient microorganisms that first appeared on the earth 2 billion years ago and used solar energy for photosynthesis to grow and reproduce. important role. In the past, it was mostly used in the treatment of organic wastewater. In recent years, the nutritional value of bacteria and some special physiological activities have gradually been recognized, and its research and development have increasingly attracted the attention of countries all over the world. [0003] Salvia miltiorrhiza is a labiatae plant. Salvia miltiorrhiza B...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P1/04A61P9/00A61K36/537C12R1/01C12N1/20A61K125/00
Inventor 杨官娥秦娟杨飞张肇铭
Owner SHANXI MEDICAL UNIV