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Application of 20(S)-ginsenoside Rh2 compound in preparing antidepressant medicament

A ginsenoside and antidepressant technology, which can be applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve the problems of unreported antidepressant effects

Inactive Publication Date: 2009-12-30
上海药谷药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the antidepressant effect of 20(S)-ginsenoside Rh2 has not been reported

Method used

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  • Application of 20(S)-ginsenoside Rh2 compound in preparing antidepressant medicament
  • Application of 20(S)-ginsenoside Rh2 compound in preparing antidepressant medicament
  • Application of 20(S)-ginsenoside Rh2 compound in preparing antidepressant medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] Preparation of 20(S)-ginsenoside Rh2 ordinary capsules

[0129] Prescription: 20(S)-Ginsenoside Rh2 25mg

[0130] Lactose 170mg

[0131] Carboxymethyl Starch Sodium 5mg

[0132] 5% povidone (K30) in 70% ethanol solution

[0133] Take 20(S)-ginsenoside Rh2, lactose, and sodium carboxymethyl starch through a 80-mesh sieve and mix evenly, add 5% povidone K30 in 70% ethanol solution to make a soft material, pass through a 40-mesh sieve to granulate. 50 ~ 60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing 20(S)-ginsenoside Rh2 25mg.

Embodiment 2

[0135] Preparation of 20(S)-ginsenoside Rh2 ordinary capsules

[0136] Prescription: 20(S)-Ginsenoside Rh2 25mg

[0137] Microcrystalline Cellulose 170mg

[0138] Crospovidone 5mg

[0139] 5% povidone (K30) in 70% ethanol solution

[0140] Take 20(S)-ginsenoside Rh2, microcrystalline cellulose, and cross-linked povidone through a 80-mesh sieve and mix evenly, add an appropriate amount of 5% povidone K30 in 70% ethanol solution to make a soft material, pass through a 40-mesh sieve to granulate . 50 ~ 60 ℃ oven blast drying. The dry granules are sieved through a 40-mesh sieve. Fill No. 1 capsules according to the prescribed amount, each containing 20(S)-ginsenoside Rh2 25mg.

Embodiment 3

[0142] Preparation of 20(S)-ginsenoside Rh2 ordinary capsules

[0143] Prescription: 20(S)-Ginsenoside Rh2 25mg

[0144] Povidone (K30) 175mg

[0145] Proper amount of ethanol

[0146] Magnesium Stearate 1mg

[0147] Take 20(S)-ginsenoside Rh2, povidone, add appropriate amount of ethanol and heat to dissolve, put the rotary evaporator to remove ethanol, cool, pulverize, pass through a 40-mesh sieve, add the prescribed amount of magnesium stearate, and mix well. Fill No. 1 capsules according to the prescribed amount, each containing 20(S)-ginsenoside Rh2 25mg.

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PUM

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Abstract

The invention relates to application of a 20(S)-ginsenoside Rh2, namely 3-O-beta-D-glycopyranoside-dammarane-24-alkenyl-3beta, 12beta, 20(S)-triol compound in the field of pharmacy. The compound can effectively confront reserpine related ptosis or akinesia, L-5-HT related mouse tremble, mouse suspension tail or forced swimming acquired desperation and depression and enhance levodopa behavioral effects under test dose, and has no excitation or inhibition function on central pivot. The safety research shows that the compound has high safety, does not influence the central nervous system, cardiovascular system and respiratory system, and has no mutagenesis function. The compound has high safety and good antidepressant function under the test dose, and the action mechanism of the compound can block the reuptake of NA and DA transmitter so as to increase the concentration correlation of two transmitters of synapse and clearance; and the compound can be used for treating depression.

Description

technical field [0001] The present invention relates to the use of chemical substances in the field of medicine. More specifically, it is the application of compound 20(S)-ginsenoside Rh2, that is, 20(S)-protopanaxadiol-3-O-β-D-glucopyranoside in the preparation of antidepressant drugs. Background technique [0002] Compound 20(S)-ginsenoside Rh2, chemical name is 3-O-β-D-glucopyranosyl-dammarane-24-ene-3β,12β,20(S)-triol, white powder shape, odorless. Soluble in methanol and ethanol, slightly soluble in ethyl acetate, almost insoluble in water, insoluble in ether and chloroform. CAS number: 78214-33-2, its structural formula is: [0003] [0004] Depression is a common and frequently-occurring disease that seriously endangers human physical and mental health. It has the characteristics of high prevalence, high recurrence rate, high disability rate and high mortality rate. According to the World Health Organization, nearly 400 million people around the world suffer fr...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/28
Inventor 惠永正吴伟泳杨翎周小龙
Owner 上海药谷药业有限公司
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