Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hazel endothelin and extracting method and drug application thereof

A hazelin, the name of the technology, applied in the field of application in the preparation of drugs for the treatment of hyperlipidemia, to achieve a significant effect of curative effect

Inactive Publication Date: 2009-12-30
JILIN UNIV
View PDF0 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no report on the extraction method and compound of hazelin A. This compound is a new compound and is isolated for the first time; the new medicinal use of this compound belongs to first discovered

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hazel endothelin and extracting method and drug application thereof
  • Hazel endothelin and extracting method and drug application thereof
  • Hazel endothelin and extracting method and drug application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] a. Extraction: Take 5.0kg of dried hazel leaves, soak them with 3 times the amount of 85% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.12, and filter , the filtrate was extracted with petroleum ether, chloroform, ethyl acetate and n-butanol successively, and the solvent was recovered under reduced pressure to dryness to obtain 25 g of n-butanol.

[0033] b. Separation: The obtained n-butanol part is subjected to silica gel column chromatography of 200-300 meshes, eluted with chloroform-methanol 1:1, the eluate is collected, and the solvent is recovered to obtain the crude hazelin A product with a yield of 0.012%. ,

[0034] c. Purification of hazelin A: the crude hazelin A was recrystallized with methanol to obtain pure hazelin A: 0.6 g.

[0035] Identification: Spectroscopy method was used for structural identification.

[0036] HR-ES...

Embodiment 2

[0050] a. Extraction: Take 5.0kg of dried hazel leaves, soak them with 4 times the amount of 75% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.15, and filter , The filtrate was sequentially extracted with petroleum ether, chloroform, ethyl acetate, and n-butanol, and the solvent was recovered under reduced pressure to dryness to obtain 28 g of n-butanol.

[0051] b. Separation: The obtained n-butanol part is subjected to silica gel column chromatography of 200 to 300 meshes, eluted with chloroform-methanol 1:5, the eluate of part A of hazelin is collected, and the solvent is recovered to obtain a crude product of hazelin A. Yield 0.013%.

[0052] c. Purification of hazelin A: the crude hazelin A was recrystallized with methanol to obtain pure hazelin A: 0.64 g.

Embodiment 3

[0054] a. Extraction: Take 5.0kg of dried hazel leaves, soak them in 5 times the amount of 95% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.14, and filter , the filtrate was sequentially extracted with petroleum ether, chloroform, ethyl acetate, and n-butanol, and the solvent was recovered under reduced pressure to dryness to obtain 30 g of n-butanol.

[0055] b. Separation: the obtained n-butanol part is subjected to silica gel column chromatography of 200 to 300 meshes, eluted with chloroform-methanol at 1:10, the eluate of hazelin A part is collected, and the solvent is recovered to obtain hazelin A crude product, Yield 0.015%.

[0056] c. Purification of hazelin A: take crude hazelin A and recrystallize it with methanol to obtain pure hazelin A: 0.7 g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a hazel endothelin and an extracting method thereof and a drug application thereof, belonging to new compound and drug application thereof and comprising the following steps: taking corylus heterophylla fisch leaf as raw material, extracting by ethanol, extracting by organic solvent, carrying out gel silica column chromatography, recrystallizing to obtain a new compound with the chemical name of 7, 8, 10-trimethoxy-4, 5-dihydrophenanthro [2,3] dioxolane which is hazel endothelin A for short and the yield is above 0.01%. The hazel endothelin A has wide drug applicationin preparing drugs for treating hyperlipaemia.

Description

technical field [0001] The invention relates to hazelin A, its extraction method, and its application in the preparation of medicines for treating hyperlipidemia. Background technique [0002] Flat hazel (Corylus heterophylla Fisch) is a plant in the genus Corylus heterophylla Fish. exBess. [0003] Hazel (Corylus heterophylla Fish.ex Bess.) is a plant of the genus Corlus in the family Beturaceae. It is native to my country and has a history of more than 6,000 years according to research. Due to the abundant wild resources of hazel, over the years my country has mostly used wild resources. With the rapid development of cultivation and the continuous development of the market, a small amount of cultivation has been carried out in some areas of my country in recent years. At present, there are 12 species of hazels cultivated in my country, including Corylus heterophylla Fisch, Corlus mandshurica Batal, and Corylus tibetica Batal. , Shanxi, Shandong, Henan and other places are...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D317/70A61K31/36A61P3/06
Inventor 刘金平李平亚卢丹薛健飞
Owner JILIN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com