Microelectrode array device and special device for cell manipulation and electrophysiological signal detection

A microelectrode array, electrical signal technology, applied in measurement devices, biological tests, applications, etc., can solve problems such as distance, cell damage, and difficulty in precise alignment of neural networks and microelectrode arrays.
CN101614729AActive Publication Date: 2009-12-30CAPITALBIO CORP +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CAPITALBIO CORP
Publication Date
2009-12-30

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Abstract

The invention discloses a microelectrode array device and a special device for cell manipulation and electrophysiological signal detection. The microelectrode array device consists of a chip unit, a printed circuit board and a bottomless cultivation cavity, wherein the chip unit is arranged on the printed circuit board by pressure welding and is embedded into the cultivation cavity; the cultivation cavity is in seal connection with the printed circuit board; the chip unit comprises a substrate, a lower metal layer, an insulation layer, an upper metal layer and a passivation layer in turn frombottom to top; the lower metal layer is provided with at least one measuring electrode and a contact conductor and a bonding pad corresponding to the measuring electrode; the upper metal layer is provided with at least four positioning electrodes and contact conductors and bonding pads corresponding to the positioning electrodes; each of all measuring electrodes and positioning electrodes of the chip unit is led out by a separate contact conductor; one contact conductor is connected with one bonding pad; and each electrode can be applied with a signal or be detected independently.
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Description

technical field

[0001] The invention relates to a micro-electrode array device and a special device for cell operation and electrophysiological signal detection. Background technique

[0002] Microelectrode array chip (microelectrode array, MEA) refers to the general term for microdevices that can detect nerve electrophysiological signals or neurotransmitters in multiple channels at the nerve cell, tissue or system level in real time. The earliest planar microelectrode array chip was created by Thomas in 1972. reported by et al., for recording the electrical activity of cardiomyocytes cultured in vitro.

[0003] As mentioned above, the microelectrode array chip was first developed for the purpose of studying the characteristics and mechanism of nervous system activity. In 1949, Lilly first used the multi-tube combination microelectrode insertion method perfused with electrolyte to study the relationship between primate behavior and neuron discharge; then the microelectrode ...

Claims

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