Biologic antibiosis protective material and preparation method thereof

A technology of protective material and biological antibacterial agent, applied in the field of biological antibacterial protective material and its preparation, can solve the problems of pathogenic microorganism retention, harm to human body, secondary pollution, etc., and achieves high sterilization rate, fast and efficient action, and high safety. Effect

Inactive Publication Date: 2010-01-27
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some traditional protective materials only rely on physical barriers for protection, and there is a possibility of pathogenic microorganism retention and secondary polluti

Method used

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  • Biologic antibiosis protective material and preparation method thereof
  • Biologic antibiosis protective material and preparation method thereof
  • Biologic antibiosis protective material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Preparation of Biological Antibacterial Protective Materials

[0018] A PET sample (25×25 cm in size) was immersed in an acetonitrile solution containing 0.2-1% (w / v) NaOH, and reacted at 23° C. and 80-180 rpm for 6-24 hours. Wash three to four times with distilled water and air dry. Immerse the treated PET sample in a solution containing 2-10% KMnO 4 0.6M sulfuric acid solution, reacted at 60°C for 0.5-5h, washed several times with 6M HCl and distilled water, and dried in air to obtain PET with carboxyl groups on the surface.

[0019] Immerse C-PET in 0.1M MES buffer containing coupling agents EDC and NHS, react at room temperature for 12-24 hours, use 0.1M MES buffer (MES buffer is prepared by dissolving MES in water) and distilled water respectively washing. Then immerse it in PBS buffer containing 0.1-2% ε-polylysine (PBS buffer is a phosphate buffer with a pH value of about 7.2, consisting of disodium hydrogen phosphate, potassium dihydrogen phosphate and water)...

Embodiment 2

[0027] According to the step described in Example 1, 0.1~2% polymyxin sulfate (dissolved in buffer solution according to the weight to volume ratio) is fixed on the PET surface, and the antibacterial effect of the material is measured according to the bactericidal experiment in Example 1, and the results are as follows:

[0028] Table 2 Antibacterial effect of immobilized polymyxin sulfate PET protective material

[0029]

Embodiment 3

[0031] According to the steps described in Example 1, 0.1~2% nisin (dissolved in buffer solution according to the weight to volume ratio) is fixed on the PET surface, and the antibacterial effect of the material is measured according to the bactericidal experiment in Example 1, and the results are as follows:

[0032] Table 3 Antibacterial effect of immobilized nisin PET protective material

[0033]

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Abstract

The invention discloses a biologic antibiosis protective material which is highly safe and applies to protective products such as biologic protective mask, biologic protective clothes and the like, and a preparation method thereof. The biologic antibiosis protective material is characterized by comprising at least one biologic antimicrobial agent and polyethylene terephthalate which are boned together by a covalence; wherein the biologic antimicrobial agent is Epsilon-polylysine, polymyxin sulfate, nisin or natamycin. According to the invention, the PET first undergoes surface modification, proper group-carboxyl can be introduced out, and then the carboxyl is activated and then caused to react with an N rear end of the antimicrobial agent, therefore, a covalence bonding method can be adopted for fixing the antimicrobial agent on the PET surface, and the antimicrobial agent can be bonded on the protective material for a long time after the fixation. The biologic antibiosis protective material does not affect the physical properties of the protective material PET, has high sterilizing rate and mostly achieves over 99 percent of sterilizing rate.

Description

technical field [0001] The invention relates to the field of antibacterial protective materials, and more specifically relates to a highly safe biological antibacterial protective material and a preparation method thereof. Background technique [0002] In recent years, the infection rate of major infectious diseases such as AIDS, tuberculosis, and viral hepatitis in my country has remained high, and public health emergencies such as natural epidemics, biosafety accidents, and bioterrorism activities have also occurred from time to time, resulting in highly pathogenic Sexual, highly infectious and unknown pathogenic microorganisms have caused serious threats and impacts on people's lives and health. Therefore, there is an urgent need to develop and develop personal protective equipment with high protection efficiency against pathogenic microorganisms and harmless to human body and environment. Protective materials are a key part of protective equipment. Some traditional prot...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08G63/91C08J7/12
Inventor 郝丽梅杨荆泉吴金辉林松田涛
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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