Liquid chromatography detector and flow controller therefor

A technology for liquid chromatography and detectors, applied in the field of liquid chromatography detectors and flow controllers for them, capable of solving problems such as not being able to sufficiently reduce noise and improve sensitivity

Inactive Publication Date: 2010-02-10
UNIV OF MISSOURI BOARD OF CURATORS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, such conventional detection devices with diff...

Method used

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  • Liquid chromatography detector and flow controller therefor
  • Liquid chromatography detector and flow controller therefor
  • Liquid chromatography detector and flow controller therefor

Examples

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example 1

[0032] now refer to Figures 3A-3C , shows a preamplifier chromatogram for 20 ppm hydrocortisone without the flow controller 130 of the present invention. These chromatograms show the noise associated with conventional ELSD. Each of these chromatograms shows the detected signal of the preamplifier of the ELSD before any signal processing takes place. Those skilled in the art will readily appreciate that these jagged peaks reduce the overall sensitivity of the ELSD since these peaks must be processed to remove the jagged peaks, thereby losing accuracy.

[0033] and Figures 3A-3C In contrast to the chromatogram of the Figures 4A-4C The preamplifier chromatogram for 20 ppm hydrocortisone shows the results of having the flow controller 130 of the present invention adjacent to the impactor 118. The signals of these chromatograms show a clear improvement over that of the chromatograms without flow controller 130 . For example, directly compare Figure 3A and 4A , with a sig...

example 2

[0036] now refer to Figures 6A-6C , shows exemplary preamplifier and back panel chromatograms for 0.18 mg / mL ginkgolide B without the flow controller of the present invention. Preamplifier chromatogram contains noticeable noise. Only after the signal is processed, some noise is removed, as shown in the corresponding rear panel chromatogram. However, this treatment reduces the sensitivity of the ELSD and is undesirable. Also, even after rear panel processing, the Figures 6A-6C In each of the chromatograms still contain noticeable noise.

[0037] In contrast, Figures 7A-7C Preamplifier and back panel chromatograms for 0.18 mg / mL ginkgolide B with flow controller 130 are shown. These preamplifier chromatograms ( Figures 7A-7C ) created with the flow controller 130 and their equivalent chromatograms created without the aid of the flow controller ( Figures 6A-6C) exhibit significantly less noise than . In particular, for example, directly compare Figure 6A and 7A , ...

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Abstract

A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquidchromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.

Description

technical field [0001] Evaporative light scattering detectors (ELSD), mass spectrometers, and charged aerosol detectors are often used in liquid chromatography (LC) analysis. In such devices, a liquid sample is converted into droplets by a nebulizer. The carrier gas carries the droplets through the nebulizer barrel, impactor, and drift tube. Traditional arrangements place impactors in the path of the liquid to intercept large droplets, which are collected and exit the drift tube through an outlet discharge channel. The remainder of the sample liquid of appropriate size passes through the drift tube, which may be heated to aid in the evaporation of the solvent portion of the droplets. As the solvent portion of the liquid evaporates, the remaining less volatile analyte is delivered to a detection chamber or detector for detection depending on the type of device used. For example, in the detection chamber of an ELSD, the light scattering of a sample is measured. In this way, ...

Claims

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Application Information

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IPC IPC(8): G01N1/00
CPCG01N30/84G01N2030/8447G01N30/74G01N2030/847G01N2030/8494G01N30/62G01N30/02G01N11/04
Inventor 徐治R·博泽J·M·安德森
Owner UNIV OF MISSOURI BOARD OF CURATORS
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