Bionic enzymatic hydrolysate for centipede and application thereof

A technology of enzymatic hydrolysis products and biomimetic enzymolysis, applied in the direction of medical preparations containing active ingredients, drug combinations, medical raw materials derived from arthropods, etc., can solve problems such as incomplete hydrolysis, reduced curative effect, and less absorption and utilization of active ingredients

Inactive Publication Date: 2010-02-17
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Small molecular oligopeptides and small peptides are easily absorbed and utilized by the small intestine, while large molecular proteins are difficult to be absorbed and utilized in the small intestine
The traditional raw powder is taken directly. Only a small amount of macromolecular protein in the raw drug powder is decomposed in the gastrointestinal tract in the body and becomes small molecular oligopeptides to be absorbed. The interference of oral administration of other foods results in incomplete hydrolysis, less active ingredients are absorbed and utilized, resulting in a waste of a large amount of medicinal materials and a greatly reduced curative effect
The extraction process of water extraction, water extraction, alcohol precipitation, or alcohol extraction denatures the protein with large molecular weight, does not dissolve into water and alcohol, is not dissolved, and is removed by filtration, resulting in a large amount of waste of medicinal materials and greatly reducing the curative effect.

Method used

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  • Bionic enzymatic hydrolysate for centipede and application thereof
  • Bionic enzymatic hydrolysate for centipede and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Take 500g of centipede, add 10 times the amount of water to homogenate, adjust the pH to 2.0, add 1% of the centipede’s pepsin, incubate at 40°C for 2 hours, adjust the pH to 8.0, add 1% of the centipede’s pancreatin or Trypsin was incubated at 50°C for 4 hours, spray-dried, added with appropriate amount of starch, granulated, dried, granulated, and filled into capsules.

Embodiment 2

[0081] Take 500g of centipede, add 8 times the amount of water to homogenate, adjust the pH to 2.6, add 2% of the centipede's amount of pepsin, incubate at 37°C for 3 hours, adjust the pH to 7.5, add 2% of the centipede's amount of pancreatin or Trypsin was incubated at 40°C for 6 hours, spray-dried, added an appropriate amount of microcrystalline cellulose, granulated, dried, sized, and pressed into tablets.

Embodiment 3

[0083] Take 500g of the centipede, add 15 times the amount of water to homogenate, adjust the pH to 3.0, add 5% of the centipede’s pepsin, incubate at 40°C for 2 hours, adjust the pH to 8.5, add 5% of the centipede’s pancreatin or Trypsin was incubated at 45°C for 5 hours, heated to 85°C for 15 minutes, filtered, and the filtrate was ultrafiltered with an ultrafiltration membrane, and the solution with a molecular weight cut-off of 5kD or less was separated to make an injection.

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Abstract

The invention discloses bionic enzymatic hydrolysate for centipedes and application thereof, and belongs to the field of Chinese medicaments. The invention adopts the technical scheme that: a bionic enzymolysis method is adopted; the centipedes are taken; and after water is added in the centipedes so as to form homogenate, under proper conditions, the heat preserving enzymolysis is carried out firstly by pepsin, and then the heat preserving enzymolysis is carried out by pancreatin or trypsase. The obtained enzymatic hydrolysate is prepared into preparations according to different preparation requirements. The bionic enzymatic hydrolysate has the excellent effects in aspects of treating cancer, cardiovascular and cerebrovascular diseases, hepatitis, chronic nephritis, rheumatic arthropathy,sciatic nerve diseases, and various dermatosis pruritus symptoms.

Description

technical field [0001] The invention relates to a biomimetic enzymatic hydrolyzate of traditional Chinese medicine centipede and its application in treating corresponding diseases. It belongs to the field of traditional Chinese medicine. Background technique [0002] Centipede is an animal of the family Centipede of Arthropoda Phylum Chiliopoda Plastic Order. It is a variety of medicinal materials recorded in the Chinese Pharmacopoeia. It was first recorded in "Shen Nong’s Materia Medica". Convulsions, tetanus, rheumatic tinea, sores, swollen toxins, scalds, etc. have been used in the prevention and treatment of diseases for more than 2,000 years. Due to the continuous and in-depth research on the treatment of various difficult diseases with Xifeng Zhispasm medicine in recent years, the medicinal use of centipede is also favored. [0003] As a traditional Chinese medicine, centipede is widely used clinically. In the way of medicine, the original medicinal material is usual...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P1/16A61P9/00A61P21/02A61P29/00A61P43/00C12P21/00A61K35/648
Inventor 李钦青张加余
Owner 北京凯瑞创新医药科技有限公司
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