Verticillium lecanii quick-release dispersible tablet and preparation method thereof
A technology of Verticillium leek and dispersible tablets, which is applied in the fields of botanical equipment and methods, fungicides, chemicals for biological control, etc., can solve the problems of dust pollution, low content of active ingredients, and poor dose controllability. , to achieve the effects of environmental and natural enemy safety, simple production process and strong dose controllability
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Embodiment 1-5
[0024] Embodiment 1-5 main medicine is Verticillium leek dry spore powder
[0025] The main drug is Verticillium cereus dried spore powder, and the preparation process is that the spores of Verticillium cereus grown in the potato culture medium are eluted with sterile kaolin, and peeled off together with the bacterial moss, under sterile conditions. Dry at room temperature for 7 days, pulverize, and pass through a 100-mesh sieve.
[0026] First design the formula and determine the total amount of products to be prepared, prepare materials according to the formula listed in Table 1, all solid additives are pre-passed through a 100-mesh sieve, weigh the main drug, and successively add surfactant and spore protectant to the mixer. , UV protectant, synergist, 2 / 3 of disintegrant and filler, stir and mix thoroughly for 60 minutes, then add wetting agent, continue to stir and mix for 30 minutes to make a uniform wet material (kneaded into 20-mesh sieve to make wet granules, dry und...
Embodiment 6-10
[0030] Example 6-10: The main drug for preparation is the concentrated fermentation broth of Verticillium cereus.
[0031] The main drug is the concentrated fermentation broth of Verticillium cereus, and its preparation process is to centrifuge the liquid fermentation product of Verticillium cereus at a speed of 6000 rpm for 20 minutes, pour out the supernatant, and use 1.5 times its volume for the sediment. The supernatant is washed out three times, and the three washes are combined.
[0032]First design the formula and determine the total amount of products to be prepared, prepare materials according to the formula listed in Table 2, all solid auxiliaries are pre-passed through a 100-mesh sieve, and liquid auxiliaries are filtered to remove slag; surfactants and spores are added to the mixer successively. Protective agent, UV protective agent, synergist, 2 / 3 disintegrant and filler, stir and mix thoroughly for 60 minutes; use a spray bottle with a pore size of 0.1 cm to spra...
Embodiment 11
[0036] Embodiment 11: the formula is: the centrifugation supernatant liquid weight percentage composition of Verticillium cereus concentrated fermentation broth (main drug) 68kg, wetting agent is 1%, and the filler is that the starch weight percentage composition is 13.5% %, the lubricant is magnesium stearate and the weight percentage is 0.5%. The preparation method is the same as that in Example 1. 10 spores / piece.
[0037] Feature comparison
[0038] The disintegration time was measured by the rotating basket method, the temperature was controlled at 24-25°C, and the number of viable bacteria after being stored at room temperature for one or two years was measured by the dilution plate method.
[0039] Prepare Verticillium leek immediate-release dispersible tablets according to Example 9, the average tablet weight is 1.3g / tablet, and the average content of the main drug is 1.64×10 10 spores / piece.
[0040] Table 3. Comparison of the main characteristics of Verticillium l...
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