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Verticillium lecanii quick-release dispersible tablet and preparation method thereof

A technology of Verticillium leek and dispersible tablets, which is applied in the fields of botanical equipment and methods, fungicides, chemicals for biological control, etc., can solve the problems of dust pollution, low content of active ingredients, and poor dose controllability. , to achieve the effects of environmental and natural enemy safety, simple production process and strong dose controllability

Active Publication Date: 2010-03-03
GANSU ACAD OF SCI INST OF BIOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its control of pests is based on the reproduction of conidia or mycelium in the pests, so its application has high requirements for environmental factors, especially temperature and humidity, and its control effect is also easily affected by ultraviolet rays. The storage period is too short. In order to overcome the above-mentioned shortcomings of Verticillium lecanii and give full play to its advantages, it is a relatively simple and feasible measure to process the formulation and add additives.
But Verticillium lecanii is a living organism, and it is more sensitive to the external environment (temperature, humidity, light, etc.), and its formulation processing is more complicated than chemical insecticides. Therefore, the development and research of new environmental protection formulations is even more important. Most importantly, it is also a necessary process for the further commercial production of Verticillium lecanii
[0004] At present, domestic research on its dosage form and its additives is still in the exploratory stage, and the relevant research is mainly made into wettable powder, but it is easy to cause dust pollution, and the dose controllability is poor, resulting in waste and safety for producers and users The coefficient is reduced, and the main active ingredient of the wettable powder produced by the prior art is the mixture of spores, mycelium and culture medium, and the content of the active ingredient per unit volume is too low, which indirectly increases the agricultural cost and limits its large-scale production. Scale promotion and application
In addition, under the current technical conditions, the drying process of the main component in the production of its wettable powder is a high-cost production link, which limits its further large-scale industrial production

Method used

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  • Verticillium lecanii quick-release dispersible tablet and preparation method thereof
  • Verticillium lecanii quick-release dispersible tablet and preparation method thereof
  • Verticillium lecanii quick-release dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0024] Embodiment 1-5 main medicine is Verticillium leek dry spore powder

[0025] The main drug is Verticillium cereus dried spore powder, and the preparation process is that the spores of Verticillium cereus grown in the potato culture medium are eluted with sterile kaolin, and peeled off together with the bacterial moss, under sterile conditions. Dry at room temperature for 7 days, pulverize, and pass through a 100-mesh sieve.

[0026] First design the formula and determine the total amount of products to be prepared, prepare materials according to the formula listed in Table 1, all solid additives are pre-passed through a 100-mesh sieve, weigh the main drug, and successively add surfactant and spore protectant to the mixer. , UV protectant, synergist, 2 / 3 of disintegrant and filler, stir and mix thoroughly for 60 minutes, then add wetting agent, continue to stir and mix for 30 minutes to make a uniform wet material (kneaded into 20-mesh sieve to make wet granules, dry und...

Embodiment 6-10

[0030] Example 6-10: The main drug for preparation is the concentrated fermentation broth of Verticillium cereus.

[0031] The main drug is the concentrated fermentation broth of Verticillium cereus, and its preparation process is to centrifuge the liquid fermentation product of Verticillium cereus at a speed of 6000 rpm for 20 minutes, pour out the supernatant, and use 1.5 times its volume for the sediment. The supernatant is washed out three times, and the three washes are combined.

[0032]First design the formula and determine the total amount of products to be prepared, prepare materials according to the formula listed in Table 2, all solid auxiliaries are pre-passed through a 100-mesh sieve, and liquid auxiliaries are filtered to remove slag; surfactants and spores are added to the mixer successively. Protective agent, UV protective agent, synergist, 2 / 3 disintegrant and filler, stir and mix thoroughly for 60 minutes; use a spray bottle with a pore size of 0.1 cm to spra...

Embodiment 11

[0036] Embodiment 11: the formula is: the centrifugation supernatant liquid weight percentage composition of Verticillium cereus concentrated fermentation broth (main drug) 68kg, wetting agent is 1%, and the filler is that the starch weight percentage composition is 13.5% %, the lubricant is magnesium stearate and the weight percentage is 0.5%. The preparation method is the same as that in Example 1. 10 spores / piece.

[0037] Feature comparison

[0038] The disintegration time was measured by the rotating basket method, the temperature was controlled at 24-25°C, and the number of viable bacteria after being stored at room temperature for one or two years was measured by the dilution plate method.

[0039] Prepare Verticillium leek immediate-release dispersible tablets according to Example 9, the average tablet weight is 1.3g / tablet, and the average content of the main drug is 1.64×10 10 spores / piece.

[0040] Table 3. Comparison of the main characteristics of Verticillium l...

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Abstract

The invention discloses a verticillium lecanii quick-release dispersible tablet and a preparation method thereof. Verticillium lecanii concentrated fermentation liquor or dry spore powder thereof is used as a main effective component. Synergist, surface active agent, protective agent, disintegrating agent, wetting agent, filler and lubricant are added as well. The preparation method is implementedby the following steps: 2 / 3 disintegrating agent and other auxiliary agents, together with verticillium lecanii, are added into a mixer for uniform mixing according to a certain proportion; then thewetting agent with an appropriate amount is added for mixing so that the mixture obtained from the previous step is changed into a wet material; the wet material then undergoes 20-mesh screening so asto be prepared into wet grains; after 24-48-hour drying at the normal temperature in a relatively germfree condition, the rest 1 / 3 disintegrating agent is added into the dry grains, and then the grains are weighed; the lubricant with a weight accounting for 0.5-0.6% of the grain weight is added for full and uniform mixing, and then the grains are sent to a tablet machine to be pressed into largetablets so that the finished product can be obtained. The verticillium lecanii quick-release dispersible tablet has simple production process and wide material source, is easy for industrial production, can be quickly disintegrated in water to release effective components, takes effect quickly, does not cause dust pollution, has a wide range of prevention and cure and can kill insect and bacteriostasis simultaneously.

Description

technical field [0001] The invention belongs to the production and processing technology of fungal microbial pesticides in the field of biological control, in particular to a specific Verticillium leechii insecticidal, bactericidal microbial pesticide. Background technique [0002] Verticillium cereus was discovered in 1861 and it was not until the 1950s that it began to be deeply studied abroad and popularized and applied. So far, more than a dozen commodities have been industrialized and circulated on the market. Significantly. However, my country has only started research in the 1970s. There are small-scale applications of experimental products, but there are no relevant reports on large-scale field promotion and application. There is still no commodity registration. The main reason is the development of technology and formulations suitable for industrial production. Relative lag, thus affecting its further commercialization. [0003] Verticillium cereus is an entomopath...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N63/04A01N25/34A01P7/04A01P3/00
Inventor 刘锦霞杜文静武建荣李娜沈思远李晶张建军韩融冰杨兰廷
Owner GANSU ACAD OF SCI INST OF BIOLOGY
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