Method for treating malignant tumors with joint medicament administration and anti-malignant tumor medicament

A technology for malignant tumors and treatment methods, which is applied in the field of combined drugs for the treatment of malignant tumors and anti-cancer drugs, and can solve the problems of reduced quality of life, limitation of chemotherapy drugs, and low immune function in patients with malignant tumors.

Active Publication Date: 2010-03-17
GUANGDONG YINZHU PHARMACEUTICAL TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor selectivity of anti-malignant tumor drugs and large toxic and side effects, the immune function of malignant tumor patients is low and the quality of life is reduced, which limits the use of chemotherapy drugs.
In addition, the emergence of multidrug resistance also limits the use of chemotherapy drugs

Method used

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  • Method for treating malignant tumors with joint medicament administration and anti-malignant tumor medicament
  • Method for treating malignant tumors with joint medicament administration and anti-malignant tumor medicament
  • Method for treating malignant tumors with joint medicament administration and anti-malignant tumor medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This example verifies the synergistic effect of glucocorticoid (dexamethasone) on carboxytriazole in inhibiting the growth of transplanted Lewis lung cancer in mice.

[0030] Experimental materials: C57BL-6 strain mice, Class II experimental animals, certificate number SCXK2005-0013 issued by the Ministry of Science and Technology of the People's Republic of China in 2005. Body weight 18-22g, male, 12 / group, purchased from the Experimental Animal Center of Chinese Academy of Medical Sciences.

[0031] Experimental method: Under aseptic operation, take Lewis'LC tumor nodules that grow well without ulceration, select healthy tumor tissue without necrosis, cut it into pieces, put it into a grinder, add an appropriate amount of normal saline (NS), and grind it Tumor single cell homogenate, after counting under the microscope, adjusted to 1×10 with NS 7 The concentration of cells per ml was inoculated subcutaneously in the right armpit of mice, and each mouse was injected w...

Embodiment 2

[0035] This example demonstrates the in vivo inhibitory effect of dexamethasone and carboxytriazole on the growth of colon cancer cells.

[0036] Experimental materials: SCID mice, SPF level experimental animals, certificate number SCXK (Beijing) 2002-0003

[0037] experimental method:

[0038] On day 0, SCID mice (6-8 weeks old) were subcutaneously inoculated with 2 × 10 6 colon cancer LS174T cells, 10 days later, the tumor-bearing animals were grouped. Dexamethasone 1.25 mg / kg was given by intraperitoneal injection, or carboxytriazole 20 mg / kg was given by intragastric administration, or the combination was administered at the same time, and a normal saline (NS) control group and a PEG400 control group were set up. Tumors were excised on day 23 for weight measurement. The formula for calculating tumor inhibition rate:

[0039] (1-average tumor weight in the treatment group / average tumor weight in the control group)×100%

[0040] Experimental results: see figure 2 .

...

Embodiment 3

[0043] In vivo synergistic inhibitory effect of dexamethasone and carboxytriazole on melanoma in C57BL / 6 mice

[0044] Experimental Materials

[0045] The C57BL / 6 strain mouse is a class II experimental animal, weighing 18-22 g, male, and the certificate number is SCXK2005-0013 issued by the Ministry of Science and Technology of the People's Republic of China in 2005. Body weight 18-22g, male, 12 / group, purchased from the Experimental Animal Center of Chinese Academy of Medical Sciences.

[0046] experimental method

[0047] Before the experiment, C57BL / 6 mice were depilated under the armpits. During inoculation, melanoma B16 cells in the logarithmic growth phase were collected, and after the cell density was evenly adjusted by pipetting, they were inoculated subcutaneously in the armpit of the left forelimb. On the 10th day, choose a tumor-derived animal that grows vigorously and has no ulceration, and the animal is in good health to remove the tumor and inoculate it again....

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Abstract

The invention discloses a method for treating malignant tumors with joint medicament administration and also discloses an anti-malignant tumor medicinal composition with an antitumor activity and a low toxicity and an anti-malignant tumor medicinal preparation using the medicinal composition as an active component. The method comprises a step of jointing administrating anti-inflammatory medicaments, such as glucocorticosteroids or immunosuppressive agents or biotic agents of target cell factors and a carboxamidotriazole or derivatives or intermediates of the carboxamidotriazole as a medicamentto treat malignant tumors, wherein the anti-inflammatory medicaments have a certain regulation effect on cell factors. Tests prove that the combined medicament can increase the sensitivity of tumor cells to the carboxamidotriazole, so the combined medicament can be used as a broad-spectrum medicament for treating a plurality of malignant tumors, particularly non-small cell lung cancer, colon cancer and the like.

Description

technical field [0001] The present invention relates to the field of medical treatment and medicine, in particular to the treatment of malignant tumors and the anti-cancer drugs by means of combined medication, in particular to the use of carboxytriazole and anti-inflammatory drugs with a certain regulatory effect on cytokines, such as glucocorticoids Synergistic drugs or immunosuppressants or biological agents targeting cytokines to treat malignant tumors and a series of combination drugs against malignant tumors. Background technique [0002] Among various diseases, cancer is one of the main diseases causing human death. According to the World Health Organization, more than 10 million new cancer cases occur in the world every year. At present, the main methods for treating cancer include: surgical treatment, chemotherapy of anticancer drugs, radiotherapy, biological response modifiers and other treatments. However, due to the poor selectivity of anti-malignant tumor drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4192A61K45/00A61K31/56A61P35/00
Inventor 张德昌叶菜英郭磊鞠瑞
Owner GUANGDONG YINZHU PHARMACEUTICAL TECHNOLOGY CO LTD
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