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Chinese medicine patch for treating rheumatism and impediment pain and method for producing the same

A technology for rheumatic arthralgia and production methods, which is applied in the direction of medical formulas, non-central analgesics, medical preparations containing active ingredients, etc., can solve problems such as poor curative effect, patient safety problems, toxic and side effects, and achieve inclusion time Short, easy to control process conditions, high product yield

Inactive Publication Date: 2010-03-31
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current Chinese patent medicines have many prescriptions for rheumatic arthralgia, but due to various etiologies, there are still patients with poor curative effect due to inappropriate symptoms
Generally, rheumatic arthralgia patients are usually treated with medicaments, mostly oral medicines or injections, but both oral medicines and injections have toxic and side effects, and they will produce a reaction through the first-pass effect of the liver and the release of the digestive tract. safe question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 (high dose)

[0014] The traditional Chinese medicine patch for treating rheumatic arthralgia and the preparation method are to make raw materials according to the weight ratio of 1 kg, and make according to the following method: 10 kg of myrrh, 10 kg of ephedra, 10 kg of Speranthum spp., and 10 kg of asarum.

[0015] Proportionally take myrrh, ephedra, osmanthus and asarum, respectively crush and grind them, and after homogenizing by a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0016] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of ...

Embodiment 2

[0020] Embodiment 2 (low dosage)

[0021] The traditional Chinese medicine patch for treating rheumatic arthralgia and the preparation method are to make raw materials according to the weight ratio of 1 kg, and make according to the following method: 3 kg of myrrh, 3 kg of ephedra, 3 kg of Speranthum 3 kg, and 3 kg of asarum.

[0022] Proportionally take myrrh, ephedra, osmanthus and asarum, respectively crush and grind them, and after homogenizing by a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0023] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of eth...

Embodiment 3

[0027] Embodiment 3 (medium dose)

[0028] The traditional Chinese medicine patch for treating rheumatism arthralgia and the preparation method are to prepare the raw materials according to the weight ratio of 1 kg according to the following method: 5 kg of myrrh, 5 kg of ephedra, 5 kg of Speranthum fructus, and 5 kg of asarum.

[0029] Proportionally take myrrh, ephedra, osmanthus and asarum, respectively crush and grind them, and after homogenizing by a micron homogenizer and a nanometer homogenizer, the particle size of each component is 100-200 μm.

[0030] After the quality inspection of the particle size, the ground raw materials were put into the colloid mill for CO 2 Supercritical extraction, adding β-cyclodextrin and appropriate amount of water, the weight ratio of raw material drug to β-cyclodextrin is 1:6. Grind the colloid mill evenly, keep the speed at 3000r / min, adjust the distance between the mills to 5 μm, continuously and slowly add an appropriate amount of e...

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PUM

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Abstract

The invention provides a Chinese medicine patch for treating rheumatism and impediment pain and a method for producing the same, and the invention contains the following components in proportion by weight: myrrh 10-20, ephedra stem 3-10, Trberculate Speranskia Herb 3-10 and Asarum Herb 3-10; the invention includes the steps of: proportionally mixing raw materials, grinding until particle diameterof each component is 100-200 mu m; using CO2 supercritical extraction, fractionating acquired distillates with a fractionating tower, mixing each component in the formula into nano medicinal pulp according to the formula proportionality through the nano dispersing apparatus, adding accelerating agent for percutaneous absorption and contact adhesive into the circular type low temperation drying coater, and after coating, executing shearing, quality test, packaging and then sending the product into warehouse. The invention uses a scientific method for processing and extracting medicinal materials, which are filled in the framework of the substrate, and the paster substrate has a good compatibility with skin, and is good for medicament molecule to pass; the medicament has the advantages of slow release, smooth and steady administration, small irritation without toxic and side effects, thereby resolving the problem that oral medication and injection have toxic and side effects for human body and preventing toxic and side effects of medicament taken orally.

Description

technical field [0001] The invention relates to a traditional Chinese medicine patch, in particular to a traditional Chinese medicine patch for treating rheumatic arthralgia and its preparation method Background technique [0002] Exogenous wind-cold, at the beginning, the evils of wind-cold, wind-heat, rheumatism, cold-dampness, and damp-heat invade, and the meridians are affected by the evils, blocking the movement of Qi, and then entering the blood, resulting in stagnation of Qi and blood stasis. This is the judgment of traditional Chinese medicine on the cause of rheumatic arthralgia. Existing Chinese patent medicines have multiple groups of prescriptions for rheumatic arthralgia, but due to various etiologies, there are still those with poor curative effect due to inappropriate symptoms. Generally, patients with rheumatic arthralgia are usually treated with medicaments, mostly oral medicines or injections, but oral medicines and injections have toxic and side effects, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61K36/328A61K9/70A61K47/40A61K47/02A61P29/00
Inventor 梁秉文高惠明杨吉田
Owner TIANJIN ZHONGBAO PHARMACY