Riboflavin-5'-lauric acid monoester crystal form and preparation method thereof as well as medicine composite containing same
A technology of lauric acid monoester and riboflavin, which is applied in the direction of drug combination, medical preparations containing active ingredients, organic chemistry, etc., to achieve the effects of shortening the production cycle, large suction filtration resistance, and saving equipment
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Embodiment 1
[0036] Take 1 gram of riboflavin-5'-lauric acid monoester sample, add it to 10ml of N,N-dimethylformamide, raise the temperature to 70°C, stir and dissolve completely, pour it into 50ml of methanol in an ice-water bath, and stir to precipitate the solid Stirring was continued for half an hour, suction filtered, the precipitate was washed with methanol and vacuum-dried to constant weight to obtain 0.85 g of powdered riboflavin-5'-lauric acid monoester crystal form product. Gained riboflavin-5'-lauric acid monoester crystal form product adopts melting point measuring instrument to measure that its melting point is 250~252 ℃ of decomposition, and its X-ray diffraction pattern is as follows figure 1 As shown, its infrared spectrum is shown as figure 2 shown.
[0037] The resulting riboflavin-5'-lauric acid monoester crystal sample and riboflavin-5'-lauric acid monoester sample were subjected to the following stability test: two batches of samples were placed in a stability resea...
Embodiment 2
[0040]Take 100 grams of riboflavin-5'-lauric acid monoester sample, add it to 800ml N,N-dimethylformamide, heat up to 80°C, stir and dissolve completely, pour it into 4000ml ice-water bath methanol, and stir to precipitate the solid Stirring was continued for half an hour, suction filtered, the precipitate was washed with methanol and vacuum-dried to constant weight to obtain 87 g of powdered riboflavin-5'-lauric acid monoester crystal form product. The X-ray diffraction spectrum of the product obtained and the melting point measured by a melting point analyzer are basically consistent with the product obtained in Example 1.
Embodiment 3
[0042] Take 1 gram of riboflavin-5'-lauric acid monoester sample, add it to 6ml of N,N-dimethylacetamide, heat up to 100°C, stir to dissolve completely, pour it into 30ml of methanol in an ice-water bath, and stir to precipitate the solid Stirring was continued for half an hour, suction filtered, the precipitate was washed with methanol and vacuum-dried to constant weight to obtain 0.8 g of powdered riboflavin-5'-lauric acid monoester crystal form product. The X-ray diffraction spectrum of the product obtained and the melting point measured by a melting point analyzer are basically consistent with the product obtained in Example 1.
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