Method for preparing tablets for treating hyperlipemia and prepared product

A technology for preparing blood lipids and Polygonum multiflorum, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, sugar-coated pills, etc. , the effect of increasing the content of glucoside

Active Publication Date: 2010-04-28
LANXI PHARMA FACTORY OF ZHEJIANG PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Our company changed the original sugar-coated tablets into film-coated tablets in 1999, but did not conduct in-depth research on the rationality of its preparation process

Method used

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  • Method for preparing tablets for treating hyperlipemia and prepared product
  • Method for preparing tablets for treating hyperlipemia and prepared product
  • Method for preparing tablets for treating hyperlipemia and prepared product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Take 100g of Polygonum multiflorum, crush it into fine powder, and set aside; take 400g of Polygonum multiflorum (coarsely crushed) and 500g of Alisma, heat and reflux with 90% ethanol to extract twice (add 3 times the amount of 90% ethanol), each time for 3 hours, and combine Extract solution: 500g of Semen Cassiae and 500g of Hawthorn, heat and reflux with 70% ethanol to extract twice (add 3 times the amount of 70% ethanol), the first time is 3 hours, the second time is 2 hours, and the combined extracts are extracted; the reflux extracts are respectively Recover ethanol, concentrate the alcoholic extracts of Radix Polygoni Multiflori and Alisma to a relative density of 1.18-1.22, concentrate the alcoholic extracts of Semen Cassiae and Hawthorn to a relative density of 1.25-1.35, and set aside; add water to decoct the above-mentioned medicinal residues after alcohol extraction Three times (steam pressure 0.03Mpa~0.06Mpa), 2 hours for the first time (add 3 times the amo...

Embodiment 2

[0094] Take 100g of Polygonum multiflorum, crush it into fine powder, and set aside; take 400g of Polygonum multiflorum (coarsely crushed) and 500g of Alisma, heat and reflux with 90% ethanol to extract twice (add 2 times the amount of 90% ethanol), each time for 3 hours, and combine Extract solution: 500g of cassia seed and 500g of hawthorn, heated and refluxed with 70% ethanol to extract twice (adding 2 times the amount of 70% ethanol), 3 hours for the first time, 2 hours for the second time, combined extracts; the reflux extracts were respectively Recover ethanol, concentrate the alcoholic extracts of Radix Polygoni Multiflori and Alisma to a relative density of 1.15 to 1.18, concentrate the alcoholic extracts of Semen Cassiae and Hawthorn to a relative density of 1.20 to 1.25, and set aside; add water to decoct the above-mentioned medicinal residues after alcohol extraction three times (steam pressure 0.08Mpa ~ 0.15Mpa), the first 2 hours (add 3 times the amount of water by...

Embodiment 3

[0096]Take 100g of Polygonum multiflorum, crush it into fine powder, and set aside; take 400g of Polygonum multiflorum (coarsely crushed) and 500g of Alisma, heat and reflux with 90% ethanol to extract twice (add 4 times the amount of 90% ethanol each time), 3 hours each time , combined extract; depend on cassia seed 500g and hawthorn 500g, use 70% ethanol to reflux extract twice (add 4 times of amount 70% ethanol each time), first time 3 hours, second time 2 hours, combine extract; Recover ethanol from the extracts, prepare the alcoholic extracts of Polygonum multiflorum and Alisma, and concentrate them to a relative density of 1.25-1.35, and concentrate the alcoholic extracts of Semen Cassiae and Hawthorn to a relative density of 1.30-1.40 for later use; add water to the above-mentioned medicinal residues after alcohol extraction Decoct three times (steam pressure 0.02Mpa ~ 0.10Mpa), the first time for 2 hours (add 4 times the amount of water by weight), the second time for 2...

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Abstract

The invention discloses a method for preparing tablets for treating hyperlipemia and a prepared product. The method comprises the following steps: using Alisma orientale, cassia seed, hawthorn fruit and prepared fleece flower root as raw materials, and pulverizing 20% of the prepared fleece flower root into fine powder; carrying out the reflux extraction on the rest prepared fleece flower root and the Alisma orientale twice by heating with 90% ethanol, and carrying out the reflux extraction on the cassia seed and the hawthorn fruit twice by heating with 70% ethanol; respectively recycling ethanol from the reflux extracting solutions, concentrating to a proper amount, decocting the drug residues after the reflux extraction for three times, taking the supernatant, concentrating to a proper amount, mixing with the ethanol-extraction concentrated liquid of cassia seed and hawthorn fruit, drying under reduced pressure, pulverizing into fine powder, adding proper amounts of the fine prepared fleece flower root powder and starch, and evenly mixing; and making the ethanol-extraction concentrated liquid of prepared fleece flower root and Alisma orientale, and mixed powder into particles, drying, adding a proper amount of lubricant, pressing into 1000 tablets, and coating films. The invention improves the prior preparation method; the product has the advantages of stable quality, high retention rate of effective components, obvious curative effect and high efficiency; and the preparation technology is mature, reasonable and feasible.

Description

technical field [0001] The invention relates to a new preparation method of a Chinese patent medicine for treating hyperlipidemia of phlegm-turbidity stagnation type and a product thereof, especially a kind of raw material of Alisma, cassia seed, hawthorn, Radix Polygoni Multiflori for preserving effective The composition improves curative effect, and the tablet made by adopting a new technology belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Alisma orientalis (Sam.) Juzep., a traditional Chinese medicine, is the dry tuber of Alisma orientalis (Sam.) Juzep.; Cassia is the dried mature seed of Cassia obtusifolia L. or Cassia tora L.; Crataegus pinnatifida Bge.var.majorN.E.Br. or the dry mature fruit of Crataegus pinnatifida Bge.; Polygonum multiflorum is the processed product of the dried tuber root of Polygonum muLtiflorum Thunb. Xuezhiling tablet, which is composed of the above four flavors, has the functions of reduci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/28A61P3/06
Inventor 王天亮樊雪君王永华
Owner LANXI PHARMA FACTORY OF ZHEJIANG PROV
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