Process for preparing glyphosate by using glycine

Abstract

The invention relates to a process for preparing glyphosate by using glycine, which comprises the following steps: (1) putting paraformaldehyde, methanol and triethylamine in a reaction vessel, maintaining the reaction temperature to be 30-50 DEG C and stirring until the mixture is transparent; (2) adding the glycine to the reaction solution, and reacting to obtain condensation solution; (3) adding diisopropyl phosphate to the condensation solution, and reacting to obtain esterification solution; (4) adding hydrochloric acid to the esterification solution for acidification treatment to obtain hydrolysis solution; and (5) under the condition of normal pressure, controlling the temperature to be 80-130 DEG C for desolvation and deacidification, then under vacuum pressure, controlling the temperature to be 80-130 DEG C for deacidification by adding water two times, and finally adding deionized water and stirring for crystallization and leaching to obtain solid glyphosate. Compared with the prior art, the process has higher yield and convenient operation, saves the cost, and is suitable for industrial production due to production repeatability.

Description

technical field [0001] The invention relates to a preparation process, in particular to a preparation process of glyphosate by glycine method. Background technique [0002] Glyphosate, whose chemical name is N-(phosphonic acid methyl) glycine, is a broad-spectrum organic phosphorus systemic herbicide. In 1971, it was successfully developed by Monsanto Company of the United States for the first time. Due to its excellent performance, high efficiency, broad spectrum, low toxicity, environmental safety, etc., and other superior biological characteristics, it is currently the world's largest herbicide. One of the pesticides, enduring for more than 30 years. In recent years, with the promotion of genetically modified crops around the world, it has developed more rapidly, and it is currently the largest herbicide variety in the world. [0003] There are many patent reports on the synthesis methods of glyphosate at home and abroad, and the synthesis methods are rare among pestici...

AI Technical Summary

Problems solved by technology

In order to solve this problem, many enterprises add more dimethyl phosphite, expecting to increase the yield of the product, but this process often leads to complex reaction components in the reaction process. For example, dimethyl phosphite is easily hydrolyzed to generate phosphorous acid and Methanol, etc., will eventually affect the quality of the product, and at the same time increase the proportion of raw materials and increase the production cost of the product