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Medicine composition for treating postpartum melancholia, preparation method and application

A technology for postpartum depression and a composition, applied in the field of medicine, can solve the problems of neonatal drug dependence, withdrawal symptoms, abnormal behavior and personality, etc., and achieve the effects of strong controllability, safe use and clear drug efficacy

Inactive Publication Date: 2010-05-26
TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antidepressant drugs usually have three main side effects: ① cause teratogenic effects in the first trimester; ② medication in the third trimester will cause drug dependence in the newborn, and withdrawal symptoms will appear in the neonatal period; ③ there is another one that is difficult to estimate And determine the degree of side effects that cause behavioral and personality abnormalities in childhood, such as ADHD, personality disorders, and interpersonal communication disorders, etc.

Method used

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  • Medicine composition for treating postpartum melancholia, preparation method and application
  • Medicine composition for treating postpartum melancholia, preparation method and application
  • Medicine composition for treating postpartum melancholia, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1 Preparation of pharmaceutical granules of the present invention

[0024] Take ginseng 1000g, jujube seed 1500g, angelica 1000g, the above three flavors, take angelica medicinal materials, crush them through a No. 1 sieve, add 12 times the amount of water, soak for 2 hours, distill and extract for 12 hours, collect the volatile oil, and collect the distilled aqueous solution in a separate device for later use; for ginseng 8 times the amount of 70% ethanol, extract 3 times, each time for 1 hour, recover the ethanol from the alcohol liquid to obtain the medicinal solution, and collect it in another device; mix ginseng, angelica dregs and jujube seed, add 10 times the amount of water, decoct 2 times, each time After 1 hour, combine the decoction, filter, combine the filtrate with the above two aqueous solutions, concentrate to a relative density of 1.10, clear the paste, and spray dry it. . Take 1 part of spray-dried powder, mix 0.8 parts of excipients (lactos...

Embodiment 2

[0027] Embodiment 2 Preparation of pharmaceutical capsules of the present invention

[0028] Get 1000g of ginseng, 1000g of Semen jujubae, 1000g of Chinese angelica, 500g of Angelica sinensis, the above three flavors, and the extraction method of Chinese angelica is the same as in Example 1; the ginseng is extracted 3 times with 80% ethanol in an amount of 8 times, each time for 1 hour. Mix ginseng, angelica dregs and jujube kernels, add 10 times the amount of water, decoct twice, 1 hour each time, combine the decoction, filter, combine the filtrate with the above two aqueous solutions, concentrate to a relative density of 1.10, clear paste, and dry , granulating, granulating, adding the above-mentioned volatile oil, filling into capsules, and preparing into capsules.

Embodiment 3

[0029] Embodiment 3 Preparation of pharmaceutical tablet of the present invention

[0030] Get 1,000g of ginseng, 3,000g of wild jujube kernels, 3,000g of Chinese angelica, 2,000g of angelica, the above three flavors, and the extraction method of angelica is the same as in Example 1; 8 times the amount of 60% ethanol for ginseng, extract 3 times, each time for 1 hour, recover the ethanol from the alcohol liquid to obtain a medicinal liquid, and collect it in another device; Mix ginseng, angelica dregs and jujube kernels, add 10 times the amount of water, decoct twice, 1 hour each time, combine the decoction, filter, combine the filtrate with the above two aqueous solutions, concentrate to a relative density of 1.10, clear paste, and dry , granulating, granulating, adding the above-mentioned volatile oil, adding magnesium stearate, compressing into tablets, and preparing into tablets.

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Abstract

The invention provides a medicine composition for treating postpartum melancholia, which is a medicament prepared from the following raw materials of medicines proportioned by weight: 1 part of ginseng, 1-3 parts of wild jujuba seed and 0.5-2 parts of angelica. The invention also provides a preparation method and an application of the medicine composition. The medicine is used for treating the postpartum melancholia and has definite medicine effect and strong controllability. Pharmacodynamical experiments prove that the medicine has the effects of treating parturient depression, invigorating qi, nourishing the blood, promoting blood circulation and relieving the stasis of blood, has safe clinical use and provides a novel choice of the medicine for treating the postpartum melancholia in clinic.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating postpartum depression, belonging to the field of medicines. Background technique [0002] Postpartum depression is the most common type of puerperal psychiatric syndrome. Symptoms usually appear within two weeks after delivery, manifested as irritability, terror, anxiety, depression, and excessive worry about the health of oneself and the baby; often lose the ability to take care of the baby and self-care, and even harm the baby or commit suicide. The clinical manifestations of postpartum depression vary, and the current incidence is increasing. On the one hand, due to the improvement of medical health level, the health of pregnant women has been fully paid attention to; on the other hand, because medical personnel have enhanced their understanding of the occurrence of this disease, the diagnosis level has been improved. The prevalence rate detected by the same method in foreign count...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61P7/06A61P25/24A61P37/04
Inventor 谢萍冯俭
Owner TEACHING HOSPITAL OF CHENGDU UNIV OF T C M
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