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Derivative of alpha-amino phosphonic acid containing saccharide groups, preparation method and medical application thereof
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A kind of derivative, the technology of methyl amine group, applied in the α-amino phosphonic acid derivative containing sugar group, its preparation and the field of medical application, can solve the immunosuppression, infection and tumor, Cushing's syndrome And other issues
Inactive Publication Date: 2010-06-02
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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However, the long-term application of hormone drugs and immunosuppressive drugs can easily lead to low immune function, such as Cushing's syndrome, and even serious side effects such as infection and tumor
Therefore, autoimmune diseases currently lack effective means of prevention and / or treatment
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Embodiment 1
[0089] Example 1: Preparation of α-[N-(D-glucosyl)-N-methylamino]-α-(2,4-dihydroxyphenyl)methylphosphonic acid monoethyl ester-compound 1
[0090] Weigh 7.00g (0.0507mol) 2,4-dihydroxybenzaldehyde, 9.80g (0.0502mol) N-methyl-D-glucosamine and 7.80g (0.0565mol) diethyl phosphite, add 60ml absolute ethanol Dissolve, stir and react at a bath temperature of about 65°C for 5 days, cool, concentrate under reduced pressure, add ethyl acetate, a yellow solid precipitates, collect the solid by filtration, wash with ethyl acetate, dry to obtain 20.20g, yield 94.6%, mp 190 -193°C (dec.).
[0092] Example 2: Preparation of α-[N-(D-glucosyl)-N-methylamino]-α-(2,3-dihydroxyphenyl)methylphosphonic acid monoethyl ester-compound 2
[0093] According to the method of Example 1, 2,3-dihydroxybenzaldehyde was used instead of 2,4-dihydroxybenzaldehyde to prepare it, with a yield of 76.0%, mp 170-173°C (dec.).
[0096] According to the method of Example 1, 3,4-dihydroxybenzaldehyde is used instead of 2,4-dihydroxybenzaldehyde to prepare the reaction, the yield is 85.4%, mp 196-199°C (dec.).
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the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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