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Penfluridol-containing oral preparation and application thereof

An oral preparation, penfluridol technology, applied in the field of oral preparations of penfluridol, can solve the problems of large side effects, poor patient compliance, etc.

Inactive Publication Date: 2010-06-16
苏春华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Residual schizophrenia - the patient is currently free of delusions, hallucinations, or disruptive speech and behavior, but lacks motivation and interest in daily life
[0008] Therefore, if the above-mentioned drugs are used for maintenance treatment, there will be side effects in varying degrees, resulting in poor compliance of patients, and inability to take drugs for a long time, resulting in relapse
[0009] Penfluridol is an old drug that was launched in the 1960s. The current specifications are 10mg and 20mg. For the treatment of schizophrenia, the therapeutic effect is not as good as the second-generation olanzapine, risperidone, sulphate, and aripiprazole, or even inferior to the first-generation clozapine and perphenazine, and the side effects are large. The foreign instructions even The therapeutic dose was increased to 250mg, and the side effects were mostly extrapyramidal reactions, drowsiness, and elevated blood sugar.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of penfluridol (3mg) capsule

[0023] Take 300g of penfluridol, add 300g of lactose, stir and mix evenly, then add 600g of lactose, mix well, then add lactose 1200g, mix well, then add 2400g lactose, mix well, then add lactose 4800g and carboxymethyl starch sodium 400g After mixing evenly, add an appropriate amount of ethanol as a wetting agent to prepare a soft material, add an appropriate amount of magnesium stearate after drying, mix evenly, and fill 100,000 capsules.

Embodiment 2

[0024] Embodiment 2: Preparation of Penfluridol Capsules (2.87mg)

[0025] Take 287g of penfluridol, add 313g of lactose, stir and mix evenly, then add 600g of lactose, mix well, then add 1200g of lactose, mix well, then add 2400g of lactose, mix well, then add lactose 4800g and sodium carboxymethyl starch 400g After mixing evenly, add an appropriate amount of ethanol as a wetting agent to prepare a soft material, add an appropriate amount of magnesium stearate after drying, mix evenly, and fill 100,000 capsules.

Embodiment 3

[0026] Embodiment 3: Preparation of Penfluridol Capsules (2.5mg)

[0027] Take 250g of penfluridol, add 350g of lactose, stir and mix evenly, then add 600g of lactose, mix well, then add lactose 1200g, mix well, then add 2400g lactose, mix well, then add lactose 4800g and carboxymethyl starch sodium 400g After mixing evenly, add an appropriate amount of ethanol as a wetting agent to prepare a soft material, add an appropriate amount of magnesium stearate after drying, mix evenly, and fill 100,000 capsules.

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PUM

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Abstract

The invention relates to a penfluridol oral preparation with novel specifications. Each dosage unit contains 2.5 to 3 mg of penfluridol. When the medicament of the invention is used, the prior common method of taking 20 mg of the medicament is changed from once a week into once a day. The oral preparation is used for the maintenance treatment of schizophrenics after undergoing other psychotherapy and pharmacotherapy and having obviously relieved symptoms, prevents relapse, avoids the side effects of taking the medicament once a week, and is economical, effective and fewer in side effects than other maintaining medicaments.

Description

Technical field: [0001] The invention relates to an oral preparation of penfluridol, each preparation unit contains 2.5-3 mg of penfluridol, used for the maintenance treatment of schizophrenia patients, and is taken once a day, which improves the disadvantages of the original taking method and is economical. , effective, safe, no side effects and no recurrence after taking it all year round. Background technique: [0002] The main manifestations of schizophrenia are mania, paranoia, depression, fear and anxiety, auditory hallucinations, sensitivity and suspicion, obsessive-compulsive impatience, disordered thinking, nonsense, throwing things, impulsive injury, and inability to control oneself. During the illness, the patient may have an unfounded wrong idea, suspecting that someone is going to harm him, firmly believing that his spouse is having an affair, hearing someone talking about him, blaming him, threatening him, seeing strange images, smelling unpleasant smells, tryi...

Claims

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Application Information

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IPC IPC(8): A61K31/451A61P25/18
Inventor 苏春华
Owner 苏春华
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