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Quality inspection method of Zhixieli granules (antidiarrheal drug)

A granule quality and antidiarrheal technology, applied in the field of quality testing of Zhixieli granules, can solve problems such as large limitations, poor specificity, negative interference, etc., and achieve the effect of high quality standard level and accurate control

Inactive Publication Date: 2010-06-16
KUNMING CHINESE MEDICINE FACTORY
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AI Technical Summary

Problems solved by technology

The eleventh volume of "Drug Standards of the Ministry of Health of the People's Republic of China" promulgated the quality control standards for Zhixieli Granules (WS 3 -B-2095-96), but in the existing Zhixieli granule quality control method issued by the Ministry of Health, there is only thin-layer chromatography identification of chlorogenic acid, and it is found that this method is negative and interferes with the specificity. Poor, very limited, it is difficult to accurately control the quality of Zhixieli granules

Method used

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Embodiment

[0016] The pharmaceutical formula of Zhixieli granule is: 267g of bayberry root, 267g of earth-boring wind, 267g of southern hawthorn, and 133g of Shanyinhua; 1000g of Zhixieli granule is made. Preparation method: the above four flavors, southern hawthorn and mountain silver flower are respectively fried with sugar water made with 5% brown sugar, so that the southern hawthorn is fried and the mountain silver flower is fried yellow. After decocting the bayberry root and the ground wind with water for 1 hour, add the southern hawthorn and mountain silver flower, decoct twice, 1 hour each time, filter, combine the filtrate, concentrate to a thick paste with a relative density of 1.33±0.02, Add an appropriate amount of sucrose powder, make granules, dry, and make 1000g.

[0017] The Zhixieli granule quality detection method of the present invention is:

[0018] 1. TLC qualitative identification method of chlorogenic acid:

[0019] Take 15g of Zhixieli granule, grind it finely, a...

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Abstract

The invention relates to a quality inspection method of Zhixieli granules (an antidiarrheal drug) prescribed in Volume 11 of Drug Standard of Ministry of Public Health of the People's Republic of China (Chinese Traditional Patent Formulation Preparations). The quality inspection method comprises a thin-layer chromatography identification method of chlorogenic acid in honeysuckle and a content determination method of chlorogenic acid in the Zhixieli granules. The quality inspection method raises the quality control standards of Zhixieli granules and establishes content determination inspection indexes of the preparation and an inspection method thereof; moreover, the quality inspection method improves the thin-layer chromatography qualitative identification method of chlorogenic acid; and the improved method has specialization and can control the quality of Zhixieli granules more accurately, thereby ensuring a higher quality standard level of the compound preparation.

Description

technical field [0001] The invention relates to a quality detection method for Zhixieli granules in Volume 11 of "Drug Standards of the Ministry of Health of the People's Republic of China" (prescriptions of traditional Chinese medicine). Background technique [0002] The drug Zhixieli Granules (WS 3 -B-2095-96), has the effect of astringent and antidiarrheal, detoxification and digestion, and is used for damp-heat diarrhea, dysentery, chronic diarrhea, chronic dysentery, diarrhea due to food injury, etc. The compound preparation is composed of 267g of bayberry root, 267g of earth-boring wind, 267g of southern hawthorn and 133g of mountain silver flower, and the above-mentioned raw materials are made into 1000g in total. Myrica nana Cheval. is the dried root of Myrica nana Cheval., a plant of the Myricaceae family. It has the effects of clearing away heat and dehumidification, astringent and antidiarrheal. The ground wind is the dried root of Rubus obcordatus Franch., a pla...

Claims

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Application Information

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IPC IPC(8): A61K36/734A61K9/16A61P1/12G01N30/02G01N30/90
Inventor 孙蓉吴叶
Owner KUNMING CHINESE MEDICINE FACTORY