Method for preparing chamigrenal from shizandra

A technology of chamilaldehyde and schisandra, which is applied in the separation/purification of carbonyl compounds, bulk chemical production, organic chemistry, etc., and can solve the problems of low active ingredient content, backward technology and equipment, and unstable quality of schisandra extract , to avoid oxidation or thermal decomposition, high purity, compact operation steps

Active Publication Date: 2013-02-06
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the backward technology and equipment, the active ingredient content of Schisandra chinensis extract is low and the quality is unstable

Method used

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  • Method for preparing chamigrenal from shizandra
  • Method for preparing chamigrenal from shizandra
  • Method for preparing chamigrenal from shizandra

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Put 300g of pulverized Schisandra powder into a 1L extraction kettle, and put the whole extraction system with CO 2 Replace and fill. Set extraction unit parameters, CO 2 The flow rate is 20L / h; the extraction pressure is 25MPa and the temperature is 45°C; the pressure of the primary separator is 8MPa and the temperature is 35°C; the pressure of the secondary separator is 6MPa and the temperature is 40°C. After continuous dynamic extraction for 4 hours, the obtained product was a yellow oil with the unique fragrance of Schisandra chinensis. The extract was weighed, 33.6g in total, and the extraction yield was 11.2%.

Embodiment 2

[0020] Put 300g of pulverized Schisandra powder into a 1L extraction kettle, and put the whole extraction system with CO 2 Replace and fill. Set extraction unit parameters, CO 2 The flow rate is 20L / h; the extraction pressure is 20MPa and the temperature is 38°C; the primary separation pressure is 8MPa and the temperature is 35°C; the secondary separation pressure is 6MPa and the temperature is 40°C. After continuous dynamic extraction for 4 hours, the yellow oily extract was collected from the bottom of the separator, totaling 27.0 g, and the extraction yield was 9.0%.

Embodiment 3

[0022] Put 300g of pulverized Schisandra powder into a 1L extraction kettle, and put the whole extraction system with CO 2 Replace and fill. Set extraction unit parameters, CO 2 The flow rate is 15L / h; the extraction pressure is 23MPa and the temperature is 38°C; the primary separation pressure is 8MPa and the temperature is 35°C; the secondary separation pressure is 6MPa and the temperature is 40°C. After continuous dynamic extraction for 5 hours, the yellow oily extract was collected from the bottom of the separator, totaling 30.3 g, and the extraction yield was 10.1%.

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PUM

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Abstract

The invention provides a method for preparing chamigrenal from shizandra, comprising the following steps: leaching shizandra medical materials through supercritical CO2 to obtain extract-shaped extractive, adsorbing by silicagel column, eluting by using petroleum ether, decompressing and concentrating, and then separating by ODS column chromatography, eluting by ethanol solution, and concentrating to obtain the final target product. Detected by efficient liquid chromatogram, the content of the main component is larger than 90%, and nuclear magnetic resonance technology is utilized for verification. The invention has reasonable design, compact operation steps and high purity quotient of the product, and can effectively avoid the oxidation or the thermal decomposition of effective components.

Description

technical field [0001] The invention belongs to the extraction, separation and purification method of active ingredients of traditional Chinese medicine, in particular to the method for preparing chamill aldehyde from Schisandra chinensis, which is obtained from supercritical CO 2 A method for separating and purifying chamill aldehyde compounds from extracted schisandra chinensis extract. Background technique [0002] Schisandra chinensis is the dry mature fruit of Schisqndra chinensis (Turcz.) Baill. Schisandra chinensis is one of the precious Chinese medicines in my country. It has many functions such as nourishing qi, nourishing kidney, restraining lung, solidifying essence, benefiting spleen, promoting body fluid and calming the nerves. Traditional medicine has detailed records on the effect of schisandra chinensis. Modern pharmacological studies have proved that the main components of Schisandra volatile oil are Citral, α-Yiangene, α-Chamigrene, β-chamgrene And Chamig...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C47/45C07C45/79
CPCY02P20/54
Inventor 王龙虎杨苏蓓金胤池刘雪松汤建成陈勇王溶溶
Owner ZHEJIANG UNIV
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