Full temperature micro volume blending incubation and hybridization instrument

Abstract

The invention provides a full temperature micro volume blending incubation and hybridization instrument which comprises a closed box cavity (2), a hot air fan (6), a cold air fan (1), a refrigeration compressor (4), a temperature sensor (11) and a heating constant temperature system (12), wherein the hot air fan (6), the cold air fan (1) and the temperature sensor (11) are arranged in the box cavity (2). The full temperature micro volume blending incubation and hybridization instrument is characterized by also comprising a motor (10) and a disc (8), wherein the disc (8) is arranged in the box cavity (2) and connected with the motor (10); and a round hole capable of allowing a centrifuge tube to be placed in is formed on the disc (8) in the direction vertical to a motor shaft. The full temperature micro volume blending incubation and hybridization instrument has more extensive temperature scope, provides proper temperature for the decoration and the hybridization of chemical and large biological molecules on the surfaces of nanometer materials, ensures the accuracy of the activity and the hybridization of the large biological molecules and is particularly suitable for the blending and the suspension of the nanometer materials in the small-volume liquid phase environment, thereby ensuring the decoration uniformity on the surface of the nanometer materials.

Description

technical field [0001] The invention belongs to the field of biological material analysis instruments, in particular to a full-temperature micro-volume mixing incubation and hybridization instrument required for temperature-required micro-nano particle surface biomacromolecule modification and molecular hybridization. Background technique [0002] Nanoparticles are the most studied and widely used nanomaterials in biomedicine, with many unique properties. At present, carbon, silicon, quantum dots and superparamagnetic nanomaterials are more studied. These materials have characteristics such as small size effect, quantum size effect, surface effect, macroscopic quantum tunneling effect, volume effect, etc., and are widely used in pathogen detection instead of existing chip detection technology, early diagnosis of tumor markers, and diagnosis of diseases. In vitro visual detection and other aspects. [0003] To apply nanoparticles to the field of biomedicine, it is necessary...

AI Technical Summary

Problems solved by technology

At present, there is no special hybridization device based on 200μL-1000μL centrifuge tubes on the market, and in the commercially available molecular hybridization instrument, the hybridization tube is parallel to the motor shaft, and the small volume of hybridization liquid has little gravity during the rotation hybridization process, or the effect of capillary phenomenon cannot Using its own gravity to flow, the nanoparticles will settle quickly, resulting in uneven mixing, which seriously affects the modification or hybridization efficiency of the particles

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