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Kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula and preparation method thereof

A technology of dioxoacetic acid and sodium dioxoacetate, which is applied in the field of medicine, can solve problems such as not being widely used, achieve good drug efficacy, facilitate operation, and prevent drug liquid pollution

Active Publication Date: 2010-06-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The puerarin daidzein-7,4'-dioxoacetic acid compound infusion using sodium chloride as an isotonic regulator of the present invention has not been specifically disclosed, and the preparation has not yet been marketed and cannot be widely used

Method used

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  • Kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula and preparation method thereof
  • Kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula and preparation method thereof
  • Kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Investigation of Pueraria daidzein-7,4'-sodium dioxoacetate and DZ5 saturated solubility in water

[0025] Take three parts each of excessive daidzein-7,4'-dioxoacetate and DZ5, put them into 10ml plugged centrifuge tubes, add 10ml of distilled water, put the above centrifuge tubes at 25°C, 60r / min in a constant temperature water-bath shaker, after shaking for 24 hours, take it out at the designated time point, centrifuge, absorb an appropriate amount of supernatant, filter it through a 0.45 μm microporous membrane, discard the initial filtrate, and then dilute it with distilled water. The peak area was determined by high performance liquid phase analysis method, and substituted into the standard curve to obtain the concentration. The results are shown in Table 1.

[0026] Table 1 Determination of Saturation Solubility of Pueraria daidzein-7,4'-sodium dioxoacetate and DZ5 in water

[0027]

Embodiment 2

[0028] Embodiment 2: Determination of the range of the pH value of the medicinal solution

[0029] The pH value of human plasma is 7.4, and the pH range of commonly used infusion solutions is 3.2-8.5. In order to determine the pH value range of this product, the pH value range of this product is designed to be 5.0-8.5, and the stability of the liquid medicine is investigated. According to the preparation process, prepare daidzein-7,4'-dioxoacetate sodium, DZ5 solution with a specification of 600mg: 100ml, and adjust the pH to 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0 and 8.5 after equalization , Sterilize at 121°C for 15 minutes, investigate the stability before and after sterilization, and determine its suitable pH. The results are shown in Table 2.

[0030] Table 2 Sterilization stability investigation results of Pueraria daidzein-7,4'-dioxoacetate sodium under different pH conditions

[0031]

[0032]

[0033] Conclusion: Pueraria daidzein-7,4'-dioxoacetate sodium is stabl...

Embodiment 3

[0034] Embodiment 3: Influence of filling nitrogen or not on infusion stability during filling

[0035]According to the preparation process, prepare daidzein-7,4'-dioxoacetate sodium infusion with specifications of 600mg: 100ml, adjust isotonicity with sodium chloride, adjust pH to 7.5 with sodium hydroxide, divide into two parts, one part Nitrogen gas is filled during filling, and no nitrogen gas is filled when one portion is filled, sterilized at 121°C for 15 minutes, placed under high temperature and accelerated light conditions for 10 days, and the appearance of each trial product is observed. The results are shown in Table 3.

[0036] Influence of Nitrogen Filling on Infusion Stabilizers during Table 3 Filling

[0037]

[0038] Conclusion: Pueraria daidzein-7,4'-dioxoacetate sodium is stable for 10 days under the condition of nitrogen filling, high temperature and accelerated light.

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Abstract

The invention belongs to the field of medical technology and relates to kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula and a preparation method thereof, in particular to a kudzu-vine root daidzein-7, 4'-dioxo acetic acid compound transfusion formula which takes sodium chloride as isoosmotic adjusting agent and a preparation method thereof; the prescription of the invention is formed as follows: each 100ml of transfusion contains 0.05-30g of DZV, 0.45-2.7g of the sodium chloride and proper amount of pH regulators; the transfusion prepared by the invention has good stability and good medicine effect on preventing and treating salient heart diseases, angina, miocardial infarction, cardiosclerosis, sudden cardiac death, cerebral apoplexy and other diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pueraria daidzein-7,4'-dioxoacetic acid compound infusion and a preparation method thereof, in particular to a pueraria daidzein-7 with sodium chloride as an isotonic regulator, A 4'-dioxoacetic acid compound infusion preparation and a preparation method thereof. Background technique [0002] Pueraria daidzein-7,4'-dioxoacetic acid compound (DZV) is a water-soluble derivative of pueraria daidzein, which is semi-synthesized from pueraria daidzein. Compared with daidzein, it has high water solubility, high bioavailability, equivalent or stronger pharmacological activity to daidzein, and less toxic and side effects. With the same series of derivatives 7,4'-bis(succinic acid monoester)oxyethoxy-daidzein (DZ5), daidzein-7-oxoacetic acid (DZd), daidzein-7 , Compared with 4'-dioxopropionic acid compound (DZe), its water solubility is larger, its properties are more stable, and its dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/02A61K31/352A61P9/10
Inventor 王淑君
Owner SHENYANG PHARMA UNIVERSITY
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