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High performance liquid chromatography analysis method of melperone hydrochloride

A technology of high-performance liquid chromatography and mepirone hydrochloride, which is applied in the field of high-performance liquid chromatography analysis of mepirone hydrochloride, can solve the problems of no uniform standard for drugs, hindering the application and promotion of drugs, etc.

Active Publication Date: 2012-08-22
WUHAN WUYAO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This status quo makes the drug no uniform standard, which greatly hinders the application and promotion of the drug.

Method used

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  • High performance liquid chromatography analysis method of melperone hydrochloride
  • High performance liquid chromatography analysis method of melperone hydrochloride
  • High performance liquid chromatography analysis method of melperone hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Mepirone hydrochloride related substances detection method:

[0028] 1. Instrument: Shimadzu LC-20A high performance liquid chromatograph, electronic analytical balance, photoelectric balance

[0029] 2. Determination method:

[0030] Accurately weigh 50 mg of the sample, put it in a 100ml measuring bottle, add mobile phase to ultrasonically dissolve and dilute to the mark, shake well, and use it as the test solution; measure 1 ml of the test solution, put it in a 100ml measuring bottle, add mobile phase to dilute to scale, then measure 1ml of the solution, put it in a 10ml measuring bottle, add mobile phase to ultrasonically dissolve and dilute to the scale, shake well, and use it as a control solution. According to the high-performance liquid chromatography test (Chinese Pharmacopoeia 2005 edition two appendix VD), with octadecyl bonded silica gel as the packed column; the mobile phase is prepared from 0.02M phosphate buffer and methanol at a volume ratio of 35:65 ;...

Embodiment 2

[0033] Mepirone hydrochloride content detection method:

[0034] 1. Instrument: Shimadzu LC-20A high performance liquid chromatograph, electronic analytical balance, photoelectric balance

[0035] 2. Determination method:

[0036] Accurately weigh sample 50mg, put in 100ml measuring bottle, add mobile phase ultrasonic dissolution and dilute to scale, shake up, as need testing solution, according to high performance liquid chromatography test (Chinese Pharmacopoeia 2005 edition two appendix VD), with Octadecyl bonded silica gel is a packed column; the mobile phase is prepared from 0.02M phosphate buffer and methanol at a volume ratio of 35:65; 0.02M phosphate buffer is composed of 0.272g potassium dihydrogen phosphate, 0.1g heptane Sodium sulfonate is prepared by adding 1000ml of water to dissolve and adjusting the pH to 8.5 with triethylamine. The detection wavelength is 248nm, and the number of theoretical plates should not be less than 3000 based on the peak of mepirone hy...

Embodiment 3

[0038] The amount of sodium heptanesulfonate added in the mobile phase was 0.05g / L, and other steps and methods were the same as in Example 1 and Example 2. According to the above method, the HPLC chromatogram obtained is as follows: image 3 .

[0039] Analysis result table:

[0040]

[0041] system assesment

[0042]

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Abstract

The invention relates to an analysis detection method of chemical medicine, in particular to a high performance liquid chromatography analysis method of melperone hydrochloride, which is characterized in that octadecyl silane is taken as a packed column, phosphate buffer-methyl alcohol is taken as a mobile phase, and heptane sodium sulfonate is added into the mobile phase. The method can accurately analyze and measure the content of the melperone hydrochloride and related substances, thus effectively controlling the quality of the melperone hydrochloride in the actual production process, and laying the foundation for establishing the unified standard for products.

Description

technical field [0001] The invention relates to an analysis and detection method of chemical drugs, in particular to a high performance liquid chromatography analysis method of meperone hydrochloride (Melperone). Background technique [0002] Due to the rapid development of modern society, people are faced with a changeable and complex environment, and they are under increasing work pressure and mental pressure, and the prevalence of mental and neurological diseases has greatly increased. The pathogenesis of schizophrenia is relatively complicated, and it is generally believed that it may be related to the neurotransmitter dopamine in the brain. [0003] Mepirone hydrochloride is a butyrophenone antipsychotic and anxiety drug, which acts by blocking dopamine receptors in the brain, and is effective for various acute and chronic schizophrenia and manic symptoms of other mental diseases. Because of its strong and long-lasting antipsychotic effect, it has been widely used clin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 杨波黄璐耿海明穆惠芳马芳岚朱毅
Owner WUHAN WUYAO SCI & TECH
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