Extract of total triterpenes in dracocephalum moldavica and preparation method and application thereof

An extraction method and technology of total triterpenes, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc.

Active Publication Date: 2010-07-28
北京化药科创医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the sub-volume of standard Uygur medicine issued by the Ministry, the functions and indications recorded not only include the therapeutic effect on cardiovascular aspects, but also have the effect of protecting the liver and strengthening the spleen, and the research on the effective parts of Xiangqinglan in the treatment of liver diseases and its preparation technology is also important. No relevant reports

Method used

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  • Extract of total triterpenes in dracocephalum moldavica and preparation method and application thereof
  • Extract of total triterpenes in dracocephalum moldavica and preparation method and application thereof
  • Extract of total triterpenes in dracocephalum moldavica and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0030] Take 1000g of dried Chinese herbal medicine, crush it into a coarse powder, add 8 times the amount of 85% ethanol to reflux and extract 3 times, filter, combine the filtrate, concentrate the filtrate under reduced pressure to form an extract, and wash the obtained extract 3 times with hot water. Filtrate, discard the washing solution, add 10 times the weight of the obtained insoluble matter to 0.5% aqueous sodium hydroxide solution, fully stir, dissolve, let stand, filter, take the filtrate, and wash the filter residue with 0.5% aqueous sodium hydroxide solution, and wash the solution with alkaline water Merge into the above filtrate, add concentrated hydrochloric acid to the filtrate to adjust the pH value to 1.0, stir fully, let it stand, filter, and wash the insoluble matter with distilled water until it is neutral after washing, discard the washing liquid, and obtain the insoluble matter with 6 times the weight of Reflux 90% ethanol to dissolve, add activated carbon ...

Embodiment 2

[0032] Take 1000g of dried Chinese herbal medicine, crush it into a coarse powder, add 10 times the amount of 95% ethanol to reflux for extraction 3 times, filter, combine the filtrate, concentrate the filtrate under reduced pressure to form an extract, and wash the obtained extract 3 times with hot water. Filtrate, discard the washing liquid, add 8 times the weight of the obtained insoluble matter to 5% aqueous sodium bicarbonate solution, fully stir, dissolve, let stand, filter, take the filtrate, and wash the filter residue with 5% aqueous sodium bicarbonate solution. Merge into the above filtrate, add concentrated hydrochloric acid to the filtrate to adjust the pH value to 2.0, stir fully, let it stand, filter, and wash the insoluble matter with distilled water until it is neutral after washing, discard the washing liquid, and obtain the insoluble matter with 5 times the weight of Reflux 90% ethanol to dissolve, add activated carbon (15g / L liquid medicine), continue to refl...

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Abstract

The invention relates to a method for extracting triterpenoids in dracocephalum moldavica. The extract of total triterpenes in dracocephalum moldavica is immediately obtained through concentration, hot water washing, alkali dissolving, acid precipitation, decolorization and purification by adsorption column chromatography of extracting solution of ethanol in dracocephalum moldavica. The content of total triterpenes in dracocephalum moldavica extract is not lower than 50% and the total content of oleanolic acid and ursolic acid is not lower than 80% of the content of total triterpenes. The extract of total triterpenes in dracocephalum moldavica has the effect of protecting livers and can be used for preparing drugs for liver diseases.

Description

technical field [0001] The invention relates to a total triterpene extract of Cymbidium orchid and its preparation method and application, belonging to the field of natural medicines. Background technique [0002] Xiangqinglan is distributed in North China, Northeast China, Northwest China and other provinces, and it is more cultivated in the southern and eastern Xinjiang of Xinjiang. CIS countries and Russia, India, Europe, etc. are also distributed. Cultivated plants are born on mountain forest edges or grass slopes. Our country is very rich in resources. The medicinal whole herb of Xiangqinglan is the dry aerial part. Harvested at the peak flowering stage in summer, removed impurities, and sun-dried. Flowers shriveled, blue-purple. The air is delicate and fragrant, and the leaves are slightly pungent. [0003] According to the information provided by Xinjiang Uyghur Hospital and Uyghur Pharmaceutical Co., Ltd., Xiangqinglan, the Uyghur name is Badiran Jibuya, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P1/16A61P31/20A61K127/00A61K133/00A61K135/00
Inventor 关屹闫冬
Owner 北京化药科创医药科技发展有限公司
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