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Application of 2-phenylphenol and derivatives thereof to medicine for treating epilepsia

A technology of biphenol and derivatives, applied in the field of medicine, to achieve the effects of strong affinity, excitotoxicity protection, and brain protection

Active Publication Date: 2010-08-18
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although epilepsy continues to be studied intensively, the pathogenesis of epilepsy is still poorly understood, and current medications provide only partial relief in patients with epilepsy [3][4] , the effective rate for patients with developing grand mal seizures is only 60% to 70%.

Method used

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  • Application of 2-phenylphenol and derivatives thereof to medicine for treating epilepsia
  • Application of 2-phenylphenol and derivatives thereof to medicine for treating epilepsia
  • Application of 2-phenylphenol and derivatives thereof to medicine for treating epilepsia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Effects of 2,2',6,6'-tetraisopropyl-4,4'-bisphenol on cortical EEG of pentylenetetrazol epilepsy model rats during seizures Materials: Male SD rats, body weight 250~ 300g, purchased from the Experimental Animal Center of Fourth Military Medical University. Pentetrazol (Sigma, USA).

[0028] Main instruments: multi-channel physiological recorder, special electrodes, dental bench drill, general-purpose electroencephalograph.

[0029] method:

[0030] (1) Preparation of pentylenetetrazol epilepsy model

[0031] 35mg / kg pentetrazol was injected intraperitoneally to induce seizures.

[0032] (2) Cortical EEG recordings of pentylenetetrazol epilepsy model rats during seizures

[0033] Rats were first anesthetized with amobarbital. The scalp was incised to expose the skull, and a small hole was drilled with a dental electric drill at the left and right sides of the junction of the coronal suture and sagittal suture 3 mm away, electrodes were implanted, and the scalp was s...

Embodiment 2

[0042] Other biphenols or derivatives thereof described in the present invention also have the same therapeutic effect as 2,2',6,6'-tetraisopropyl-4,4'-biphenols described in Example 1.

Embodiment 3

[0043] Embodiment 3: pharmaceutical composition

[0044] 2,2',6,6'-tetraisopropyl-4,4'-diphenol passed through 100 mesh sieve for later use; 2,2',6,6'-tetraisopropyl-4,4'- Diphenol 80.0g, microcrystalline cellulose 45.0g, croscarmellose sodium 5.0g, mixed evenly, using aqueous solution as wetting agent to make soft material, granulated with 30 mesh screen, ventilated and dried at 55°C, and prepared granules, set aside; add 0.5 g of micropowder silica gel, 1.0 g of magnesium stearate, mix well, press to obtain about 1000 round tablets, and obtain compressed tablets.

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Abstract

The invention belongs to the technical field of medicines and mainly relates to application of 2-phenylphenol and derivatives thereof to a medicine for treating epilepsia. The structural formula of the 2-phenylphenol derivatives is shown in the specification of the invetion, wherein R1 and R2 can be hydroxide groups, sulfhydryl groups at the same time or one is hydroxide radical and the other is sulfhydryl group; and R1 and R2 can be alkyls of C1-C6, alkenyls of C2-C6, alkyls and aryls of C2-C6 or acyls or alkenyls of C2-C6 and at least one of R1 and R2 is hydroxide group.

Description

technical field [0001] The invention belongs to the technical field of medicine, and mainly relates to the application of biphenol and its derivatives in drugs for treating epilepsy. Background technique [0002] Epilepsy is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction [1][2] . Epilepsy is a clinical phenomenon caused by abnormal and excessive hypersynchronous discharge of brain neurons. It is characterized by sudden and transient symptoms that vary depending on where in the brain the abnormally firing neurons are located. Clinically, it can be divided into generalized tonic-clonic seizures (grand mal seizures), absence seizures (petit seizures), simple partial seizures, complex partial seizures (psychomotor seizures), and autonomic seizures (intermittent seizures) according to their seizure types. ). [0003] Due to the increasing prevalence of epilepsy at home and abroad, it has become a health problem t...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61K31/095A61K31/12A61P25/08A61K31/195A61K31/53A61K31/197A61K31/7048A61K31/4015A61K31/27
Inventor 王汝涛陈涛胡惠静王惟娇张阳
Owner XIAN LIBANG PHARMA
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