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Method for extracting antiviral active substance from phellinus igniarius

A technology of antiviral activity and substances, applied in the direction of antiviral agents, medical raw materials derived from fungi, etc., to achieve high antiviral efficacy, no drug resistance, and low side effects

Active Publication Date: 2012-07-04
GUANGDONG YUEWEI EDIBLE FUNGI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on antiviral research, and the present invention mainly studies the antiviral efficacy of Phellinus Phellinus

Method used

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  • Method for extracting antiviral active substance from phellinus igniarius
  • Method for extracting antiviral active substance from phellinus igniarius
  • Method for extracting antiviral active substance from phellinus igniarius

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] 1. Dehydrating and pulverizing 100 grams of Phellinus Phellinus fruiting bodies at a low temperature below 20°C;

[0068] 2. Add ethyl acetate 8 times its volume to the pulverized Phellinus radix fruiting body to extract 3 times, 2 hours each time, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 3.27 g of powder A.

[0069] 3. Add 8 times the volume of 90% (volume concentration) ethanol to the filter residue after ethyl acetate extraction for leaching 3 times, each time for 2 hours, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 2.16 g of powder B.

[0070] 4. Add 15 times the volume of 20°C water to the ethanol-extracted filter residue, ultrasonically extract 4 times, 3 hours each time, combine the filtrate after filtration, concentrate the filtra...

Embodiment 2

[0073] 1. Dehydrating and pulverizing 100 grams of Phellinus Phellinus fruiting bodies at a low temperature below 20°C;

[0074] 2. Add 10 times the volume of ethyl acetate to the pulverized Phellinus fruiting body to extract twice, each time for 1 hour, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 2.13 g of powder A.

[0075] 3. Add 90% (volume concentration) ethanol of 10 times the volume of the filter residue to the filter residue after ethyl acetate extraction for leaching twice, each time for 1 hour, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 1.27 g of powder B.

[0076] 4. Add 28 times the volume of 20°C water to the ethanol-extracted filter residue, ultrasonically extract twice, each time for 4 hours, combine the filtrate after filtration, c...

Embodiment 3

[0079] 1. Dehydrating and pulverizing 100 grams of Phellinus Phellinus fruiting bodies at a low temperature below 20°C;

[0080] 2. Add ethyl acetate 3 times its volume to the pulverized Phellinus fruiting bodies to extract once, 1.5 hours each time, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 1.15 g of powder A.

[0081] 3. Add 3 times the volume of 90% (volume concentration) ethanol to the filter residue extracted with ethyl acetate to extract once, 1.5 hours each time, and use ultrasonic vibration for 1.5 hours. After suction filtration, the filtrates were combined, and the filtrate was concentrated and freeze-dried to obtain 0.78 g of powder B.

[0082] 4. Add 9 times the volume of the filter residue to the ethanol-extracted filter residue at 20° C., ultrasonically extract once, 4 hours each time, combine the filtrate after filtration, concentrate the filtra...

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Abstract

The invention discloses a method for extracting antiviral active substance from phellinus igniarius, which relates to a method for extracting active substance from traditional Chinese medicine. The method includes the following steps that: phellinus igniarius fruit bodies are dehydrated and ground under low temperature; ethyl acetate which is 2 to 10 times as large as the volume of the ground fruit bodies is added in the ground fruit bodies to carry out extraction, ultrasonic oscillation is carried out, filtrates are merged after filtration, and the filtrate is concentrated, frozen and dried into powder A. 90 percent of ethanol which is 2 to 10 times as large as the volume of filter residue extracted by the ethyl acetate is added into the filter residue to carry out extraction, ultrasonicoscillation is carried out, filtrates are merged after filtration, and the filtrate is concentrated, frozen and dried into powder B. Water with the temperature of 20 DEG C, which is 5 to 30 times as large as the volume of filter residue extracted by the ethanol is added in the filter residue, ultrasonic extraction is carried out, filtrates are merged after filtration, and the filtrate is concentrated, frozen and dried into powder C. According to the weight percentage ratio of 10 percent to 80 percent : 10 percent to 80 percent : 10 percent to 80 percent, the powder A, the powder B and the powder C are uniformly mixed. The obtained active substance has a good effect in resisting simian immunodeficiency virus (SIV), herpes virus (HSV) and enterovirus (EV71).

Description

【Technical field】 [0001] The invention relates to a method for extracting active substances from traditional Chinese medicines. 【Background technique】 [0002] Phellinus genus Basidiomycotina, Polyporaceae, Xylemia genus, also known as Sanchen, Mulberry, Husunyan, Phellinus bauberi, Clefthoof needle (cleft hoof), is a precious medicinal fungus , has the reputation of "forest gold". According to the records of "On the Nature of Medicine": Phellinus japonica is slightly bitter in taste and cold in nature. It has the effects of benefiting the five internal organs, softening and hardening, detoxifying, stopping bleeding, promoting blood circulation, and stomach and diarrhea. Cure mainly gonorrhea, uterine bleeding, leukorrhagia, accumulation of lumps in the abdomen, addiction to drinking, diarrhea due to spleen deficiency. In traditional Chinese medicine in my country, it is used to treat dysentery, night sweats, metrorrhagia, stranguria with blood, astringent pain in the nav...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/06A61P31/14A61P31/18A61P31/22
Inventor 潘鸿辉余雄涛李向敏谢意珍张智焦春伟蔡勉华陈冠州李森柱李崇杨小兵
Owner GUANGDONG YUEWEI EDIBLE FUNGI TECH
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